Document Detail


Ovarian sickling as a proposed mechanism for premature ovarian failure necessitating ovum donation.
MedLine Citation:
PMID:  19465672     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron overload in female patients with sickle cell disease (SCD) has been reported to result in gonadal dysfunction. To date there has been no report in the literature of ovarian sickling being a reason for gonadodysgenesis (premature ovarian failure [POF]) in women. This case report describes POF in a woman with SCD and suggests ovarian sickling as its cause. We propose that frequent episodes of intravascular sickling, vessel occlusion and infarction as well as tissue hypoxia associated with chronic anaemia could account for the ovarian dysgenesis and hence POF.
Authors:
A R Chase; J Howard; E Oteng-Ntim
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Menopause international     Volume:  15     ISSN:  1754-0453     ISO Abbreviation:  -     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101303618     Medline TA:  Menopause Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  70-1     Citation Subset:  IM    
Affiliation:
Department of Women's Health, 10th Floor, North Wing, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Hemoglobin SC Disease / complications*,  therapy*
Humans
Oocyte Donation*
Ovarian Failure, Premature / etiology*,  therapy*
Treatment Outcome

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