| Ovarian sickling as a proposed mechanism for premature ovarian failure necessitating ovum donation. | |
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MedLine Citation:
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PMID: 19465672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iron overload in female patients with sickle cell disease (SCD) has been reported to result in gonadal dysfunction. To date there has been no report in the literature of ovarian sickling being a reason for gonadodysgenesis (premature ovarian failure [POF]) in women. This case report describes POF in a woman with SCD and suggests ovarian sickling as its cause. We propose that frequent episodes of intravascular sickling, vessel occlusion and infarction as well as tissue hypoxia associated with chronic anaemia could account for the ovarian dysgenesis and hence POF. |
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Authors:
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A R Chase; J Howard; E Oteng-Ntim |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Menopause international Volume: 15 ISSN: 1754-0453 ISO Abbreviation: - Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101303618 Medline TA: Menopause Int Country: England |
Other Details:
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Languages: eng Pagination: 70-1 Citation Subset: IM |
Affiliation:
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Department of Women's Health, 10th Floor, North Wing, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Hemoglobin SC Disease / complications*, therapy* Humans Oocyte Donation* Ovarian Failure, Premature / etiology*, therapy* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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