Document Detail


Ovarian regulation of kisspeptin neurones in the arcuate nucleus of the rhesus monkey (macaca mulatta).
MedLine Citation:
PMID:  23331967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tonic gonadotrophin secretion throughout the menstrual cycle is regulated by the negative-feedback actions of ovarian oestradiol (E₂) and progesterone. Although kisspeptin neurones in the arcuate nucleus (ARC) of the hypothalamus appear to play a major role in mediating these feedback actions of the steroids in nonprimate species, this issue has been less well studied in the monkey. In the present study, we used immunohistochemistry and in situ hybridisation to examine kisspeptin and KISS1 expression, respectively, in the mediobasal hypothalamus (MBH) of adult ovariectomised (OVX) rhesus monkeys. We also examined kisspeptin expression in the MBH of ovarian intact females, and the effect of E₂, progesterone and E₂ + progesterone replacement on KISS1 expression in OVX animals. Kisspeptin or KISS1 expressing neurones and pronounced kisspeptin fibres were readily identified throughout the ARC of ovariectomised monkeys but, on the other hand, in intact animals, kisspeptin cell bodies were small in size and number and only fine fibres were observed. Replacement of OVX monkeys with physiological levels of E₂, either alone or with luteal phase levels of progesterone, abolished KISS1 expression in the ARC. Interestingly, progesterone replacement alone for 14 days also resulted in a significant down-regulation of KISS1 expression. These findings support the view that, in primates, as in rodents and sheep, kisspeptin signalling in ARC neurones appears to play an important role in mediating the negative-feedback action of E₂ on gonadotrophin secretion, and also indicate the need to study further their regulation by progesterone.
Authors:
E Alçin; A Sahu; S Ramaswamy; E D Hutz; K L Keen; E Terasawa; C L Bethea; T M Plant
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  25     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-12     Completed Date:  2013-09-25     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  488-96     Citation Subset:  IM    
Copyright Information:
© 2013 British Society for Neuroendocrinology.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arcuate Nucleus / metabolism,  physiology*
Estradiol / administration & dosage
Female
Hypothalamus / metabolism
Kisspeptins / metabolism*
Macaca mulatta
Monoamine Oxidase / genetics
Neurons / metabolism*
Ovariectomy
Ovary / physiology*
Progesterone / administration & dosage
RNA, Messenger / genetics
Grant Support
ID/Acronym/Agency:
HD 013254/HD/NICHD NIH HHS; HD15433/HD/NICHD NIH HHS; MH86542/MH/NIMH NIH HHS; P51 0D011092//PHS HHS; P51 0D011106//PHS HHS; P51 OD011092/OD/NIH HHS; P51 OD011106/OD/NIH HHS; R01 HD011355/HD/NICHD NIH HHS; R01 HD013254/HD/NICHD NIH HHS; R01 HD015433/HD/NICHD NIH HHS; R01 MH086542/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Kisspeptins; 0/RNA, Messenger; 4G7DS2Q64Y/Progesterone; 4TI98Z838E/Estradiol; EC 1.4.3.4/Monoamine Oxidase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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