Document Detail

Ovarian leydig cell hyperplasia: an unusual case of virilization in a postmenopausal woman.
MedLine Citation:
PMID:  25045549     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Objective. To report an unusual case of ovarian Leydig cell hyperplasia resulting in virilization in a postmenopausal woman. Methods. Patient's medical history and pertinent literature were reviewed. Results. A 64-year-old woman presented with virilization with worsening hirsutism, deepening of her voice, male musculature, and male pattern alopecia. Her pertinent past medical history included type 1 diabetes, hyperlipidemia, and hypertension. Her pertinent past surgical history included hysterectomy due to fibroids. On further work-up, her serum total testosterone was 506 ng/dL (nl range: 2-45) and free testosterone was 40 pg/mL (nl range: 0.1-6.4). After ruling out adrenal causes, the patient underwent an empiric bilateral oophorectomy that showed Leydig cell hyperplasia on pathology. Six weeks postoperatively, serum testosterone was undetectable with significant clinical improvement. Conclusion. Postmenopausal hyperandrogenism can be the result of numerous etiologies ranging from normal physiologic changes to ovarian or rarely adrenal tumors. Our patient was found to have Leydig cell hyperplasia of her ovaries, a rarely reported cause of virilization.
Jaya M Mehta; Jeffrey L Miller; Anthony J Cannon; Stacey K Mardekian; Lawrence C Kenyon; Serge A Jabbour
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Publication Detail:
Type:  Journal Article     Date:  2014-06-19
Journal Detail:
Title:  Case reports in endocrinology     Volume:  2014     ISSN:  2090-6501     ISO Abbreviation:  Case Rep Endocrinol     Publication Date:  2014  
Date Detail:
Created Date:  2014-07-21     Completed Date:  2014-07-21     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  101576457     Medline TA:  Case Rep Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  762745     Citation Subset:  -    
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