Document Detail


Ovarian imaging by magnetic resonance in adolescent girls with polycystic ovary syndrome and age-matched controls.
MedLine Citation:
PMID:  23292744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare ovarian morphology in adolescent girls with and without polycystic ovary syndrome (PCOS) using magnetic resonance imaging (MRI).
MATERIALS AND METHODS: In 21 adolescent girls (age 12-18 years) without and 19 adolescents with PCOS (diagnosis based on excessive hair growth and irregular menstrual cycles) ovarian volume, antral follicle count (AFC) per ovary, and follicle size were evaluated. MRI was performed at 1.5 T or 3 T and axial or angled-axial single-shot echo-train spin echo images of 6 mm slice thickness were acquired. In a subset of subjects, 2-mm images were also obtained. PCOS and non-PCOS groups were compared using mixed affects regression.
RESULTS: Mean AFC per ovary and ovarian volume were substantially greater in PCOS subjects compared to non-PCOS subjects. Mean follicle size was similar between groups. Follicles exceeding 10 mm were seen in 2/19 PCOS subjects versus 9/21 non-PCOS subjects. Consistently higher follicle counts were detected in images obtained at 2 mm compared to 6-mm slice thickness.
CONCLUSION: In adolescence, MRI of the ovary reveals distinct differences between girls with and without PCOS. MRI may help evaluate young patients in whom transvaginal ultrasound is contraindicated.
Authors:
Michele Brown; Alice S Park; Rana F Shayya; Tanya Wolfson; H Irene Su; R Jeffrey Chang
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-04
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  38     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-02     Completed Date:  2014-04-03     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  689-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc., a Wiley company.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Algorithms*
Child
Female
Humans
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Ovary / pathology*
Polycystic Ovary Syndrome / pathology*
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
M01 RR000827/RR/NCRR NIH HHS; U54 HD012303/HD/NICHD NIH HHS; U54 HD12303-28/HD/NICHD NIH HHS
Comments/Corrections

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