Document Detail


Ovarian hyperstimulation syndrome: an analysis of patient characteristics in the Asian population.
MedLine Citation:
PMID:  21451925     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction: We aimed to identify the variables associated with ovarian hyperstimulation in Asian patients and compare them with western standards. Methods: This is a retrospective case record analysis of 79 patients with ovarian hyperstimulation at a tertiary restructured hospital. Results: Gonadotropin doses resulting in hyperstimulation did not vary between long and antagonist cycles in women less than 35 years with polycystic ovaries (PCO). Mean oestradiol levels at hyperstimulation were not different between PCO and non-PCO patients in a long cycle. Hyperstimulation was mostly due to higher starting doses. Total follicle counts of more than 20 on Day 5-7 after stimulation may be predictive of subsequent hyperstimulation. Hyperstimulation tended to be more severe in lean PCO patients, and prophylactic albumin helped to reduce its severity. Conclusion: Gonadotropin doses at stimulation should start at 150 iu or less in women below 35 years of age, with a step up of 37.5 iu, as necessary. Transfer should be abandoned in the presence of high oestradiol levels (more than 5,000 pg/ml), when the total number of intermediate and large follicle count exceeds 30 on the day of oocyte retrieval, or when more than 19 eggs are retrieved. Variables in the Asian population appear to be similar to those in the western population.
Authors:
H Rajesh; W Y Lee; S Fook-Chong; S L Yu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Singapore medical journal     Volume:  52     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  168-74     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608. hemashreerajesh@yahoo.com.
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