Document Detail

Ovarian hyperstimulation for in vitro fertilization preceded by prolonged administration of a gonadotropin-releasing hormone agonist.
MedLine Citation:
PMID:  2123069     Owner:  NLM     Status:  MEDLINE    
In 51 patients, controlled ovarian hyperstimulation with clomiphene citrate (CC)/human menopausal gonadotropin (hMG), or hMG only, in 102 IVF cycles had previously resulted in a cancellation rate of 52% and no pregnancies. In 54 subsequent cycles the women were treated with prolonged administration of a gonadotropin-releasing hormone agonist (GnRHa) followed by hMG stimulation, the GnRHa group. The results were compared with the outcome of 47 cycles in patients who came for their first IVF attempt. In this group a CC/hMG regimen was used, the CC/hMG group. In the GnRHa group, 17 pregnancies were achieved, compared with 10 in the CC/hMG group. Only four cycles were cancelled in the GnRHa group, vis-à-vis 13 in the CC/hMG group, a significant difference. The study showed that prolonged use of GnRHa as a preparatory treatment is effective following previous failures of IVF.
T Tanbo; P O Dale; T Abyholm
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  69     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1990  
Date Detail:
Created Date:  1990-12-28     Completed Date:  1990-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  333-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
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MeSH Terms
Buserelin / administration & dosage,  therapeutic use*
Clinical Protocols / standards
Clomiphene / administration & dosage,  therapeutic use*
Drug Therapy, Combination
Estradiol / blood
Fertilization in Vitro*
Infertility, Female / blood,  drug therapy*,  therapy
Menotropins / administration & dosage,  therapeutic use*
Ovulation Induction / methods*
Pregnancy Outcome
Reg. No./Substance:
50-28-2/Estradiol; 57982-77-1/Buserelin; 61489-71-2/Menotropins; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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