| Ovarian failure in HAX-1 deficient patients: is there a gender-specific difference in pubertal development in severe congenital neutropenia or Kostmann disease? | |
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MedLine Citation:
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PMID: 23050867 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: Severe congenital neutropenia (SCN) is a rare disorder of myelopoiesis characterized by neutropenia, recurrent bacterial infections, and a maturation arrest of the myelopoiesis in the bone marrow. Homozygous mutations in the HAX1 gene were described in patients with autosomal recessive SCN or Kostmann disease. Some of these patients display neurological disease. We noted, during the course of clinical management of patients with Kostmann disease, insufficient pubertal development in female patients, but not in our male patients. The study objective was to provide a detailed account of this phenotype and its possible relation to HAX1 mutations. METHODS: Detailed clinical histories and laboratory investigations of three patients with Kostmann disease belonging to the original kindred in northern Sweden described by Rolf Kostmann are reported. RESULTS: We report one male patient with normal puberty and two female patients with insufficient pubertal development. Elevated levels of LH and FSH were recorded in both patients. All three patients harbor the same p.Glu190X mutation in the HAX1 gene. CONCLUSIONS: We show for the first time that female patients with Kostmann disease display primary gonadal insufficiency. This suggests a possible role for HAX-1 in the development and/or function of the human ovary. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. |
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Authors:
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Göran Carlsson; Berit Kriström; Magnus Nordenskjöld; Jan-Inge Henter; Bengt Fadeel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-11 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. |
Affiliation:
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Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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