| Ovarian epithelial-stromal interactions: role of interleukins 1 and 6. | |
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MedLine Citation:
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PMID: 21765834 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Ovarian epithelial cancer is the most lethal gynecologic malignancy. The high mortality is attributed to the fact that most cases typically present in late stage when ovarian cancer (OC) has already spread beyond the ovary. Ovarian epithelial cancer cells are shed into intraperitoneal ascites and easily disseminate throughout the peritoneal cavity with preferential metastasis to the omentum, peritoneum, and local organs. Understanding how ovarian epithelial cells interact with and modulate their microenvironment can provide insight into the molecular mechanism(s) involved with malignant transformation and progression which may eventually identify novel diagnostic, prognostic, and therapeutic targets. The objective of this paper is to provide a brief consideration of ovarian surface epithelial-stromal interactions in regard to normal physiological function and tumor progression as influenced by two potentially key interleukins, interleukins-1 (IL-1) and -6 (IL-6), present in the microenvironment. Lastly, we will consider the clinical implications of IL-1 and IL-6 for OC patients. |
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Authors:
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Kamisha T Woolery; Patricia A Kruk |
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Publication Detail:
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Type: Journal Article Date: 2011-06-26 |
Journal Detail:
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Title: Obstetrics and gynecology international Volume: 2011 ISSN: 1687-9597 ISO Abbreviation: Obstet Gynecol Int Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101517078 Medline TA: Obstet Gynecol Int Country: United States |
Other Details:
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Languages: eng Pagination: 358493 Citation Subset: - |
Affiliation:
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Department of Pathology & Cell Biology, MDC 11, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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