Document Detail

Ovarian and endocrine responses associated with the treatment of cystic ovarian follicles in dairy cows with gonadotropin releasing hormone and prostaglandin F2alpha, with or without exogenous progesterone.
MedLine Citation:
PMID:  15600159     Owner:  NLM     Status:  MEDLINE    
The objectives of this observational study were to document ovarian and endocrine responses associated with the treatment of cystic ovarian follicles (COFs) in dairy cows, using gonadotropin releasing hormone (GnRH) and prostaglandin F2alpha (PGF) with or without exogenous progesterone. A secondary objective was to determine pregnancy establishment following synchronization of ovulation and timed insemination in cows diagnosed with COFs. In trial I, 18 Holstein cows diagnosed with COFs received 2 injections of 100 microg GnRH, 9 d apart, with 25 mg PGF given 7 d after the 1st GnRH. A new follicle developed in all 18 cows after the 1st GnRH, and 83% of cows ovulated following the 2nd GnRH. Cows were inseminated 16 h after the 2nd GnRH. Of the 17 cows available for pregnancy diagnosis, 7 were confirmed pregnant. In trial II, 8 cows with COFs received GnRH and an intravaginal progesterone device (CIDR) concurrently, then PGF 7 d later. The CIDR was removed 2 d after PGF administration. Plasma estradiol concentrations declined following CIDR insertion. In all cows, a new follicle developed following GnRH treatment; estradiol-surge and estrus occurred spontaneously after CIDR-removal. Seven of 8 cows ovulated the new follicle. In dairy cows diagnosed with COFs, treatment with GnRH followed by PGF 7 d later, with or without exogenous progesterone, resulted in the recruitment of a healthy new follicle; synchronization of ovulation and timed insemination resulted in a 41% pregnancy rate.
Divakar J Ambrose; Eric J P Schmitt; Flavia L Lopes; Ricardo C Mattos; William W Thatcher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian veterinary journal. La revue vétérinaire canadienne     Volume:  45     ISSN:  0008-5286     ISO Abbreviation:  Can. Vet. J.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-16     Completed Date:  2005-02-03     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0004653     Medline TA:  Can Vet J     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  931-7     Citation Subset:  IM    
Livestock Development Division, Alberta Agriculture Food and Rural Development, 6903-116 Street, Edmonton, Alberta T6H 5Z2.
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MeSH Terms
Administration, Intravaginal
Cattle Diseases / drug therapy*
Dinoprost / therapeutic use*
Estradiol / blood*
Estrus Synchronization / methods
Follicular Cyst / drug therapy,  veterinary*
Gonadotropin-Releasing Hormone / therapeutic use*
Insemination, Artificial / veterinary
Ovarian Follicle / ultrasonography
Ovulation Induction / veterinary
Pregnancy Rate
Progesterone / therapeutic use*
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 551-11-1/Dinoprost; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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