Document Detail

Ovarian cryopreservation for fertility preservation: indications and outcomes.
MedLine Citation:
PMID:  18682546     Owner:  NLM     Status:  MEDLINE    
Female fertility preservation provides significantly different challenges to that for the male, with the only established method being cryopreservation of embryos thus necessitating the involvement of a male. Other, experimental, options include oocyte or ovarian tissue cryopreservation. The latter has been regarded as a potential method for more than a decade, but has resulted in the birth of only five babies. It is not possible to be certain how many women have had ovarian tissue cryopreserved. Oocyte cryopreservation also remains experimental, but approximately 100-fold more babies have been born through this technique over the last two decades. Ovarian tissue cryopreservation has the potential advantages of preservation of a large number of oocytes within primordial follicles, it does not require hormonal stimulation when time is short and indeed may be appropriate for the pre-pubertal. Disadvantages include the need for an invasive procedure, and the uncertain risk of ovarian contamination in haematological and other malignancies. We here review this approach in the context of our own experience of 36 women, highlighting issues of patient selection especially in the young, and uncertainties over the effects of cancer treatments on subsequent fertility. Of these 36 women, 11 have died but 5 have had spontaneous pregnancies. So far, none have requested reimplantation of their stored ovarian tissue. Ovarian cryopreservation appears to be a potentially valuable method for fertility preservation, but the indications and approaches best used remain unclear.
R A Anderson; W H B Wallace; D T Baird
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-05
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  136     ISSN:  1741-7899     ISO Abbreviation:  Reproduction     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-01-30     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  681-9     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Cryopreservation / methods*,  trends
Infertility, Female / etiology
Neoplasms / therapy
Organ Preservation / methods*,  trends
Radiotherapy / adverse effects
Grant Support
MC_U127684439//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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