Document Detail


Ovarian cancer update: lessons from morphology, molecules, and mice.
MedLine Citation:
PMID:  19886711     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ovarian carcinomas are a heterogeneous group of neoplasms. Pathologists currently employ a morphology-based classification system to divide ovarian carcinomas into major subgroups based on degree (tumor grade) and type of differentiation (eg, serous, endometrioid, clear cell, or mucinous). Molecular studies have shown that specific genetic defects are likely to be present in certain histologic types of ovarian carcinomas and unlikely to be present in others. Within the serous and endometrioid carcinomas, the molecular defects in low-grade versus high-grade tumors also appear to be largely distinct. Recently, mouse models of ovarian carcinoma have been developed that recapitulate many of the morphologic features and biologic behavior of selected subtypes of ovarian cancer. It is expected that these mouse models will yield new insights into ovarian cancer pathogenesis and prove useful for preclinical testing of novel strategies for ovarian cancer treatment.
Authors:
Kathleen R Cho
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  133     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2009-11-17     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1775-81     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / classification,  genetics,  pathology*
Adenocarcinoma, Clear Cell / classification,  genetics,  pathology
Adenocarcinoma, Mucinous / classification,  genetics,  pathology
Animals
Carcinoma, Endometrioid / classification,  genetics,  pathology
Cystadenocarcinoma, Serous / classification,  genetics,  pathology
Disease Models, Animal*
Female
Gene Expression
Humans
Mice
Mutation
Ovarian Neoplasms / classification,  genetics,  pathology*
Grant Support
ID/Acronym/Agency:
R01 CA094172/CA/NCI NIH HHS; R01 CA094172-08/CA/NCI NIH HHS; R01 CA94172/CA/NCI NIH HHS; W81WH-04-1-0211/WH/WHI NIH HHS; W81XWH-08-1-0453//PHS HHS
Comments/Corrections

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