Document Detail

Ovarian Sertoli-Leydig cell tumor with heterologous gastrointestinal epithelium as a source of alpha-fetoprotein: a case report.
MedLine Citation:
PMID:  18588618     Owner:  NLM     Status:  MEDLINE    
Ovarian Sertoli-Leydig cell tumors (SLCT) are rare sex cord stromal neoplasms. To date there have been approximately 25 case reports of ovarian SLCT expressing alpha-fetoprotein (AFP). In such cases, AFP was immunohistochemically detected in the Sertoli cells, Leydig cells, or hepatocytes. This case report confirms heterologous gastrointestinal epithelium expression of AFP. A 20-year-old woman presented with complaints of abdominal enlargement and irregular menstrual cycles over one year. A right ovarian tumor was detected and the patient's serum AFP was elevated. A right salpingo-oophorectomy was performed. On microscopic examination, the tumor was composed of a fibrosarcoma-like area and a poorly differentiated SLCT area with heterologous gastrointestinal epithelium. Immunohistochemical analysis detected AFP in the gastrointestinal epithelium only. Postoperatively, serum AFP levels fell to normal. A recurrent tumor was discovered in the omentum after adjuvant chemotherapy, but serum AFP remained normal. A second laparotomy was performed and the recurrent tumor showed only fibrosarcoma-like features. The patient received second line chemotherapy and is currently in remission. This is the first case of AFP production by heterologous gastrointestinal epithelium in SLCT.
Takafumi Watanabe; Hidekazu Yamada; Yutaka Morimura; Masafumi Abe; Teiichi Motoyama; Akira Sato
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  34     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  418-21     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan.
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MeSH Terms
Chemotherapy, Adjuvant
Epithelial Cells / chemistry
Fallopian Tubes / surgery
Gastrointestinal Tract / chemistry*
Omentum / pathology,  surgery
Ovarian Neoplasms / chemistry,  diagnosis*,  surgery
Peritoneal Neoplasms / secondary,  surgery
Remission Induction
Sertoli-Leydig Cell Tumor / chemistry,  diagnosis*,  surgery
alpha-Fetoproteins / analysis*
Reg. No./Substance:

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