| Ovarian Sertoli-Leydig cell tumor with heterologous gastrointestinal epithelium as a source of alpha-fetoprotein: a case report. | |
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MedLine Citation:
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PMID: 18588618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ovarian Sertoli-Leydig cell tumors (SLCT) are rare sex cord stromal neoplasms. To date there have been approximately 25 case reports of ovarian SLCT expressing alpha-fetoprotein (AFP). In such cases, AFP was immunohistochemically detected in the Sertoli cells, Leydig cells, or hepatocytes. This case report confirms heterologous gastrointestinal epithelium expression of AFP. A 20-year-old woman presented with complaints of abdominal enlargement and irregular menstrual cycles over one year. A right ovarian tumor was detected and the patient's serum AFP was elevated. A right salpingo-oophorectomy was performed. On microscopic examination, the tumor was composed of a fibrosarcoma-like area and a poorly differentiated SLCT area with heterologous gastrointestinal epithelium. Immunohistochemical analysis detected AFP in the gastrointestinal epithelium only. Postoperatively, serum AFP levels fell to normal. A recurrent tumor was discovered in the omentum after adjuvant chemotherapy, but serum AFP remained normal. A second laparotomy was performed and the recurrent tumor showed only fibrosarcoma-like features. The patient received second line chemotherapy and is currently in remission. This is the first case of AFP production by heterologous gastrointestinal epithelium in SLCT. |
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Authors:
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Takafumi Watanabe; Hidekazu Yamada; Yutaka Morimura; Masafumi Abe; Teiichi Motoyama; Akira Sato |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: 34 ISSN: 1341-8076 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-30 Completed Date: 2008-09-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: Japan |
Other Details:
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Languages: eng Pagination: 418-21 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan. t-wata@fmu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chemotherapy, Adjuvant Epithelial Cells / chemistry Fallopian Tubes / surgery Female Gastrointestinal Tract / chemistry* Humans Omentum / pathology, surgery Ovarian Neoplasms / chemistry, diagnosis*, surgery Ovariectomy Peritoneal Neoplasms / secondary, surgery Remission Induction Sertoli-Leydig Cell Tumor / chemistry, diagnosis*, surgery alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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