Document Detail

Ovalbumin-induced IL-4, IL-5 and IFN-gamma production in infants with atopic dermatitis.
MedLine Citation:
PMID:  15897669     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although hen's eggs are considered a cause of infantile atopic dermatitis (AD), little is known about cytokine production upon egg stimulation in infants with AD.
OBJECTIVE: This study aimed to characterize the production of IL-4, IL-5 and IFN-gamma upon stimulation with ovalbumin (OVA), a representative allergenic protein of egg, in infants with AD.
METHODS: Peripheral blood mononuclear cells (PBMCs) from 68 children with AD, including 46 infants (<1 year), were stimulated with OVA and the production of IL-4, IL-5 and IFN-gamma was measured with ELISA kits.
RESULTS: Upon stimulation with OVA, the production of IL-4 and IL-5, but not IFN-gamma, by PBMCs was significantly higher in infants with AD than in non-atopic controls. OVA-induced IL-5 production peaked in younger infants (2-5 months) and then decreased with age increase. In contrast, OVA-induced IL-4 production peaked at the age of 1-2. This coincided with the serum level of egg white-specific IgE (EW-IgE). There was a significant positive correlation between IL-5 production and the severity of symptoms in infants with AD, while IL-4 production significantly correlated with the serum level of EW-IgE.
CONCLUSION: These results demonstrate that OVA-induced IL-5 production fluctuates with age in a different manner than IL-4 or EW-IgE. Our results suggest that egg contributes to the development of AD in younger infants by inducing the production of IL-5, but not IL-4.
Mitsuaki Kimura; Makiko Obi
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Publication Detail:
Type:  Journal Article     Date:  2005-05-13
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  137     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-28     Completed Date:  2005-07-19     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  134-40     Citation Subset:  IM    
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MeSH Terms
Age Factors
Cell Proliferation
Child, Preschool
Dermatitis, Atopic / immunology*
Interferon-gamma / biosynthesis*
Interleukin-4 / biosynthesis*
Interleukin-5 / biosynthesis*
Lymphocytes / immunology
Ovalbumin / immunology*
Reg. No./Substance:
0/Interleukin-5; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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