Document Detail


Outpatient Versus Hospitalization Management for Uncomplicated Diverticulitis: A Prospective, Multicenter Randomized Clinical Trial (DIVER Trial).
MedLine Citation:
PMID:  23732265     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: We compare the results of 2 different strategies for the management of patients with uncomplicated left colonic diverticulitis and to analyze differences in quality of life and economic costs. BACKGROUND:: The most frequent standard management of acute uncomplicated diverticulitis still is hospital admission both in Europe and United States. METHODS:: This multicenter, randomized controlled trial included patients older than 18 years with acute uncomplicated diverticulitis. All the patients underwent abdominal computed tomography. There were 2 strategies of management: hospitalization (group 1) and outpatient (group 2). The first dose of antibiotic was given intravenously to all patients in the emergency department and then group 1 patients were hospitalized whereas patients in group 2 were discharged. The primary end point was the treatment failure rate of the outpatient protocol and need for hospital admission. The secondary end points included quality-of-life assessment and evaluation of costs. RESULTS:: A total of 132 patients were randomized: 4 patients in group 1 and 3 patients in group 2 presented treatment failure without differences between the groups (P = 0.619). The overall health care cost per episode was 3 times lower in group 2, with savings of &OV0556;1124.70 per patient. No differences were observed between the groups in terms of quality of life. CONCLUSIONS:: Outpatient treatment is safe and effective in selected patients with uncomplicated acute diverticulitis. Outpatient treatment allows important costs saving to the health systems without negative influence on the quality of life of patients with uncomplicated diverticulitis. Trial registration ID: EudraCT number 2008-008452-17.
Authors:
Sebastiano Biondo; Thomas Golda; Esther Kreisler; Eloy Espin; Francesc Vallribera; Fabiola Oteiza; Antonio Codina-Cazador; Marcel Pujadas; Blas Flor
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-31
Journal Detail:
Title:  Annals of surgery     Volume:  -     ISSN:  1528-1140     ISO Abbreviation:  Ann. Surg.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Department of General and Digestive Surgery--Colorectal Unit, Bellvitge University Hospital, University of Barcelona and IDIBELL, Barcelona, Spain †Department of General and Digestive Surgery-Colorectal Unit, Vall d'Hebron University Hospital, Barcelona, Spain ‡Department of General and Digestive Surgery-Colorectal Unit, Virgen del Camino Hospital, Pamplona, Spain §Department of General and Digestive Surgery--Colorectal Unit, Josep Trueta University Hospital, Girona, Spain ‖Surgery-Colorectal Unit, Hospital Clinico Universitario, Valencia, Spain.
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