Document Detail

Outdoor air pollution and respiratory health in patients with COPD.
MedLine Citation:
PMID:  21459856     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Time series studies have shown adverse effects of outdoor air pollution on mortality and hospital admissions in patients with chronic obstructive pulmonary disease (COPD) but panel studies have been inconsistent. This study investigates short-term effects of outdoor nitrogen dioxide, ozone, sulfur dioxide, particulate matter (PM(10)) and black smoke on exacerbations, respiratory symptoms and lung function in 94 patients with COPD in east London.
METHODS: Patients were recruited from an outpatient clinic and were asked to complete daily diary cards (median follow-up 518 days) recording exacerbations, symptoms and lung function, and the amount of time spent outdoors. Outdoor air pollution exposure (lag 1 day) was obtained from local background monitoring stations.
RESULTS: Symptoms but not lung function showed associations with raised pollution levels. Dyspnoea was significantly associated with PM(10) (increase in odds for an IQR change in pollutant: 13% (95% CI 4% to 23%)) and this association remained after adjustment for other the pollutants measured. An IQR increase in nitrogen dioxide was associated with a 6% (0-13%) increase in the odds of a symptomatic fall in peak flow rate. The corresponding effect sizes for PM(10) and black smoke were 12% (2-25%) and 7% (1-13%), respectively.
CONCLUSION: It is concluded that outdoor air pollution is associated with important adverse effects on symptoms in patients with COPD living in London.
Janet L Peacock; H Ross Anderson; Stephen A Bremner; Louise Marston; Terence A Seemungal; David P Strachan; Jadwiga A Wedzicha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-01
Journal Detail:
Title:  Thorax     Volume:  66     ISSN:  1468-3296     ISO Abbreviation:  Thorax     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-17     Completed Date:  2011-08-24     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-6     Citation Subset:  IM    
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MeSH Terms
Air Pollutants / analysis,  toxicity
Air Pollution / adverse effects*,  analysis
Dyspnea / etiology,  physiopathology
Environmental Monitoring / methods
Follow-Up Studies
Forced Expiratory Volume / physiology
Middle Aged
Peak Expiratory Flow Rate / physiology
Pulmonary Disease, Chronic Obstructive / etiology*,  physiopathology
Urban Health / statistics & numerical data
Vital Capacity / physiology
Grant Support
G0800570//Medical Research Council; //Department of Health
Reg. No./Substance:
0/Air Pollutants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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