Document Detail


Outcomes of very-low-birth-weight infants exposed to maternal clinical chorioamnionitis: a multicentre study.
MedLine Citation:
PMID:  25011418     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Chorioamnionitis is a recognized risk factor of preterm delivery; however, controversy still persists concerning the relationship between maternal inflammation and neonatal morbidity and mortality. Objective: To determine the incidence of clinical chorioamnionitis and its relationship to morbidity and mortality among very-low-birth-weight (VLBW) infants. Methods: This was a retrospective analysis of prospectively collected data of VLBW neonates ≤32 weeks' gestational age (GA) admitted to collaborating units in the Spanish SEN1500 Network between January 2008 and December 2011. Clinical chorioamnionitis was defined by obstetricians based on clinical findings, and neonatal outcomes were compared between exposed and non-exposed infants by multivariate logistic regression analysis. Results: During the study period, 11,464 VLBW newborns were admitted to our units and 10,026 were ≤32 weeks' GA. Among them, 8,330 (83.1%) had complete data and were included. Of these, 1,480 (17.8%) were exposed to maternal clinical chorioamnionitis. The incidence was higher at lower GA and, after adjusting for confounding factors, exposed infants had higher risks of early-onset neonatal sepsis (EONS) (10.0 vs. 2.8%; aOR 3.102; 95% CI 2.306-4.173; p < 0.001) and necrotizing enterocolitis (NEC) (11.2 vs. 7.7%; aOR 1.300; 95% CI 1.021-1.655; p < 0.033), but lower risks of patent ductus arteriosus (PDA) (43.2 vs. 34.9%; aOR 0.831; 95% CI 0.711-0.971; p < 0.02) and late-onset bacterial sepsis (LONS) (36.6 vs. 32.5%; aOR 0.849; 95% CI 0.729-0.989; p < 0.035). There were no differences in mortality between the groups. Conclusions: The incidence of maternal clinical chorioamnionitis is inversely related to GA at delivery, and in VLBW infants ≤32 weeks' GA it is associated with higher risks of EONS and NEC, but lower risks of PDA and LONS. We did not found differences in survival. © 2014 S. Karger AG, Basel.
Authors:
Fermín García-Muñoz Rodrigo; Gloria Galán Henríquez; Josep Figueras Aloy; Alfredo García-Alix Pérez
Related Documents :
7411748 - Osteoarthrosis in a wolf (canis lupus) radio-tracked in minnesota.
25338548 - Familial very long chain acyl-coa dehydrogenase deficiency as a cause of neonatal sudde...
21196428 - Randomized crossover trial of kangaroo care to reduce biobehavioral pain responses in p...
14677578 - Periodicity of death feigning by domestic fowl in response to simulated predation.
12407548 - Primary cutaneous mucormycosis in infants and neonates: case report and review of the l...
17468128 - Zinc, copper, selenium and manganese blood levels in preterm infants.
Publication Detail:
Type:  Journal Article     Date:  2014-07-05
Journal Detail:
Title:  Neonatology     Volume:  106     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2014  
Date Detail:
Created Date:  2014-07-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Is Pentraxin 3 a New Cardiovascular Risk Marker in Polycystic Ovary Syndrome?
Next Document:  Catalan and Hungarian Validation of the Zuckerman-Kuhlman-Aluja Personality Questionnaire (ZKA-PQ).