Document Detail

Outcomes of transcatheter occlusion of patent ductus arteriosus in infants weighing ≤ 6 kg.
MedLine Citation:
PMID:  21232725     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We sought to analyze the outcomes of transcatheter patent ductus arteriosus (PDA) occlusion using a variety of devices in infants weighing ≤6 kg.
BACKGROUND: Indications for transcatheter closure of a PDA in infancy include congestive heart failure and/or failure to thrive. Devices available for small infants may be problematic for various reasons, including sheath size, stiffness of delivery system, and anchoring and retrievability characteristics of the device. The Amplatzer Ductal Occluder is approved by U.S. Food and Drug Administration for children weighing >6 kg and older than 6 months of age.
METHODS: We performed a multicenter, retrospective analysis of children weighing ≤6 kg in whom transcatheter PDA occlusion was attempted between January 1995 and November 2005 at Texas Children's Hospital and January 2001 to November 2005 at Children's Hospital of San Diego.
RESULTS: A total of 62 patients underwent attempted closure. The mean age at catheterization was 4.7 ± 2.8 months with a mean weight at catheterization of 4.6 ± 0.9 kg. Successful device placement was achieved in 58 of 62 patients (94%). Among those receiving a device, complete occlusion was noted in all 58 patients at either catheterization or last available follow-up.
CONCLUSIONS: Percutaneous closure of PDA should be considered even in infants ≤6 kg.
V Vivian Dimas; Cheryl Takao; Frank F Ing; Raphael Mattamal; Alan W Nugent; Ronald G Grifka; Charles E Mullins; Henri Justino
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  3     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-01-14     Completed Date:  2011-05-09     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1295-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Child, Preschool
Ductus Arteriosus, Patent / therapy*,  ultrasonography
Infant, Newborn
Retrospective Studies
Septal Occluder Device*
Treatment Outcome
Ultrasonography, Doppler, Color
United States
United States Food and Drug Administration

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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