| Outcomes of spontaneous and assisted pregnancies in Turner syndrome: the U.S. National Institutes of Health experience. | |
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MedLine Citation:
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PMID: 21496813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess fetal and maternal outcomes of pregnancies in women with Turner syndrome (TS). DESIGN: Retrospective case series. SETTING: Clinical research center. PATIENT(S): 276 adults with cytogenetically proven TS participating in an intramural natural history protocol. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Menstrual and obstetric histories, 50-cell karyotypes, and cardiovascular evaluation including aortic diameter measurements. RESULT(S): Our cohort included five women with spontaneous pregnancies and five with pregnancies using assisted reproduction (ART). All five women with spontaneous pregnancies had spontaneous puberty, despite 45,X in ≥90% of their 50-cell karyotype. Participants had a total of 13 pregnancies and 14 live births. One child had cerebral palsy; the others were chromosomally and developmentally normal. Delivery was by cesarean section in four out of seven spontaneous and six out of six ART-related pregnancies. One mother experienced preeclampsia in an ART-related twin pregnancy that required a preterm delivery; she has marked but stable aortic dilation years later. CONCLUSION(S): Approximately 2% of our study cohort experienced spontaneous pregnancies despite high-grade X monosomy, and a similar number achieved pregnancy via oocyte donation and ART. The potential for life-threatening cardiovascular complications warrants comprehensive screening before conception or single-embryo transfer, and caution regarding unintentional pregnancies for TS women. |
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Authors:
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Tracy N Hadnott; Harley N Gould; Ahmed M Gharib; Carolyn A Bondy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2011-04-15 |
Journal Detail:
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Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-07-28 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2251-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1103, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Cerebral Palsy / genetics Chromosomes, Human, X Female Fertility* / genetics Humans Karyotyping Live Birth Middle Aged Monosomy National Institutes of Health (U.S.) Pregnancy Pregnancy Complications, Cardiovascular / genetics Pregnancy Rate Puberty Reproductive Techniques, Assisted* / adverse effects Retrospective Studies Risk Assessment Risk Factors Turner Syndrome / complications, genetics, physiopathology* United States Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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Z01 HD000628-18/HD/NICHD NIH HHS; //Howard Hughes Medical Institute |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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