Outcomes of pregnancies diagnosed with Klinefelter syndrome: the possible influence of health professionals.

Outcomes of pregnancies diagnosed with Klinefelter syndrome: the possible influence of health professionals.

MedLine Citation:	PMID: 12124688 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	OBJECTIVE: To describe the association between the outcomes of pregnancies diagnosed with Klinefelter syndrome (KS) and the specialty of the health professional providing pre- and post-diagnostic counselling. METHOD: Data were extracted from the case notes of the 111 cases of KS diagnosed prenatally between 1986 and 1997 in eight geographical regions in five European countries. The data extracted included: outcome of pregnancy, maternal age, social class, parity, gestational age at diagnosis, year of diagnosis and specialties of the health professionals conducting pre- and post-diagnosis consultations. RESULTS: The overall termination rate was 44% (49/111: 95% confidence interval: 35 to 54). Using multivariable logistic regression analysis, the only significant predictor of continuation of the pregnancy was the specialties of the health professionals conducting post-diagnosis counselling: the affected pregnancy was more likely to continue when post-diagnosis counselling involved only a genetics specialist (relative risk: 2.42 (1.14 to 5.92)). CONCLUSION: There is an association between whether or not a woman terminates a pregnancy affected by an unfamiliar fetal anomaly and the professional background of the health professional providing post-diagnostic counselling. The causal nature of this association remains to be determined.

Authors:	Theresa M Marteau; Irma Nippert; Sue Hall; Caroline Limbert; Margaret Reid; Martin Bobrow; Alan Cameron; Martina Cornel; Mariet van Diem; Bernd Eiben; Sixto García-Miñaur; Janine Goujard; Donna Kirwan; Karen McIntosh; Peter Soothill; Corien Verschuuren-Bemelmans; Catherine de Vigan; Stephen Walkinshaw; Lenore Abramsky; Frank Louwen; Peter Miny; Jürgen Horst;
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Publication Detail:	Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Detail:	Title: Prenatal diagnosis Volume: 22 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2002 Jul
Date Detail:	Created Date: 2002-07-18 Completed Date: 2003-01-23 Revised Date: 2006-11-15
Medline Journal Info:	Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England
Other Details:	Languages: eng Pagination: 562-6 Citation Subset: IM
Copyright Information:	Copyright 2002 John Wiley & Sons, Ltd.
Affiliation:	Psychology and Genetics Research Group, Guy's, King's and St Thomas' Schools of Medicine, Dentistry and Biomedical Sciences, 5th Floor, Thomas Guy House, Guy's Campus, London, SE1 9RT, UK. theresa.marteau@kcl.ac.uk
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MeSH Terms
Descriptor/Qualifier:	Abortion, Eugenic* / ethics, statistics & numerical data Adult Attitude of Health Personnel* Europe / epidemiology Female Genetic Counseling Humans Klinefelter Syndrome / diagnosis, epidemiology Pregnancy Pregnancy Outcome Prenatal Diagnosis* Retrospective Studies

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