Document Detail

Outcomes of patients presenting with acute coronary syndromes and negative Troponin-T.
MedLine Citation:
PMID:  12659984     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to compare need for revascularization and clinical course between troponin-positive and troponin-negative patients with unstable angina pectoris defined as class IIIB according to Braunwald classification. METHODS: The study group consisting of 104 patients was divided into troponin-positive (28 patients) and troponin-negative (76 patients) subgroups. Per study design all patients underwent coronary angiography. The subgroups were compared in regard to angiographic status and consequently the need for revascularization. Additionally, major adverse cardiac events (MACE) consisting of death, myocardial infarction, in-hospital revascularization during 30-days follow-up were assessed in subgroups. RESULTS: In 58 (76%) patients with negative troponin test, the angiographically significant coronary artery stenosis was shown. Major adverse cardiac events were similar in both groups. Regardless of the initial TnT status, in both groups revascularizations (percutaneous or surgical) were performed with high frequency (89 versus 72%, P=NS). CONCLUSION: In patients with unstable angina in class IIIB according to Braunwald classification, the negative cardiac troponin test did not exclude severe coronary artery disease, which in the majority of patients required revascularization without any additional non-invasive testing for ischemia. Therefore, we postulate that patients with clinically evident unstable angina (IIIB) should be referred to early invasive assessment despite negative troponin T screening.
Dariusz Dudek; Michal Chyrchel; Jacek Legutko; Pawel Petkow Dimitrow; Pawel Zymek; Grzegorz L Kaluza; Jacek S Dubiel
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  88     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-27     Completed Date:  2003-06-10     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
Department of Cardiology, Institute of Cardiology Jagiellonian University College of Medicine, Krakow, Poland.
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MeSH Terms
Acute Disease
Angina, Unstable / blood*,  diagnosis,  therapy*
Coronary Angiography
Follow-Up Studies
Middle Aged
Myocardial Revascularization*
Outcome Assessment (Health Care)*
Practice Guidelines as Topic
Severity of Illness Index
Time Factors
Troponin T / blood*
Reg. No./Substance:
0/Troponin T

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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