Document Detail


Outcomes of neonatal patent ductus arteriosus ligation in Canadian neonatal units with and without pediatric cardiac surgery programs.
MedLine Citation:
PMID:  23701758     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND/PURPOSE: Preterm infants needing patent ductus arteriosus (PDA) ligation are transferred to a pediatric cardiac center (CC) unless the operation can be done locally by a pediatric surgeon at a non-cardiac center (NCC). We compared infant outcomes after PDA ligation at CC and NCC.
METHODS: We analyzed 990 preterm infants who had PDA ligation between 2005 and 2009 using the Canadian Neonatal Network database. In-hospital mortality and major morbidities were compared between CC (n=18) and NCC (n=9).
RESULTS: SNAP-II-adjusted mortality rates were similar (CC=8.7% vs NCC=10.7%, P=.32). Significant cranial ultrasound abnormalities (CC=24.1% vs NCC=32.1%, P<.01) and culture-proven sepsis (CC=39.7% vs NCC=54.8%, P<.01) were more frequent in infants treated at NCC. Infants transferred to CC had higher rates of cranial ultrasound abnormalities (transferred 31.6% vs non-transferred 20.4%, P<.01). NSAIDs prior to PDA ligation were used more often at NCC (CC 36.6% vs NCC 75.6%, P<.001).
CONCLUSIONS: Mortality rates after PDA ligation were similar at CC and NCC, but cranial ultrasound abnormalities and sepsis rates were higher at NCC. Higher morbidity may be associated with different PDA management strategies, including NSAID use or infant transfer. Further studies are needed to investigate the reasons for these differences in morbidity.
Authors:
Charles Wong; Michael Mak; Sandesh Shivananda; Junmin Yang; Prakeshkumar S Shah; Wendy Seidlitz; Julia Pemberton; Peter G Fitzgerald; Brian H Cameron;
Related Documents :
3291738 - Congenital cardiac tumors in association with orofacial clefts.
12142648 - Resorbable internal splint: an adjunct to primary correction of unilateral cleft lip-na...
24008398 - National variability in neonatal resuscitation practices at the limit of viability.
24300958 - Vitamin k deficiency bleeding: a case study.
20707238 - Determinants of infant and young child feeding practices in sri lanka: secondary data a...
24001478 - Human milk is the only milk for premies in the nicu!
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  48     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  909-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
McMaster Pediatric Surgery Research Collaborative, Hamilton ON, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Undescended testis: The underlying mechanisms and the effects on germ cells that cause infertility a...
Next Document:  Outcomes following neonatal patent ductus arteriosus ligation done by pediatric surgeons: A retrospe...