Document Detail

Outcomes in patients with interrupted aortic arch and associated anomalies: a 20-year experience.
MedLine Citation:
PMID:  16626964     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The surgical results for the repair of interrupted aortic arch (IAA) have evolved in recent years. We report our results for staged repair of this complex congenital malformation. METHODS: Sixty-five patients (mean age, 16.9+/-41.7 days) were diagnosed with IAA and referred for surgical therapy. The surgical management strategy at our institution between 1982 and 2005 has been one-stage complete repair (n=13) or staged repair (n=52) in selected patients. Non-complex patients (group I, n=51) had a ventricular septal defect (87%), aortopulmonary window (8%), and left ventricular outflow tract obstruction (27%). Group II (n=14) were patients with Taussig-Bing double outlet right ventricle (n=6) or truncus arteriosus (n=8). Method of staged repair of IAA was to transect and turn down the left carotid artery and anastomosis it to the descending aorta (n=41) or graft interposition (n=2) combined with a pulmonary artery (PA) banding followed in a few months by delayed ventricular septal defect (VSD) closure and PA de-banding. RESULTS: There were 5 early and 10 late deaths. The actuarial survival including early mortality was 92% at 1 year, 81% at 5 years, and 76% at 10 and 15 years. There was an 81% 15-year survival for children in group I compared with a 54% for children in group II (p<0.001). Risk factors for increased mortality by univariate analysis were as follows: (1) primary aortic anastomosis (p=0.03), (2) presence of complex anomalies (p=0.05), and (3) initial IAA repair performed before 1994 (p=0.05). Actuarial freedom from any type of aortic reoperation or intervention was 86% at 1 year, 69% at 5 years, and 60% at 10 and 15 years. Univariate and multivariate analyses identified no tested variables as risk factors for reoperation. The majority (86%) was in New York Heart Association (NYHA) class I, and 14% remained in NYHA class II. During the postoperative course there were no neurologic deficits, seizures, and growth disturbances in any patient. CONCLUSION: Staged repair of IAA using a left carotid artery turn down can be safely applied in IAA patients with and without other intracardiac anomalies with good results. Use of the left carotid artery for arch reconstruction did not result in any detectable neurological events or growth disturbances later in life. Associated anomalies played an important role in outcomes. The long-term probability for reoperation and/or reintervention remains high regardless of operative technique.
John W Brown; Mark Ruzmetov; Yuji Okada; Palaniswamy Vijay; Mark D Rodefeld; Mark W Turrentine
Related Documents :
14764174 - Incidence of antitachycardia therapy suspension due to magnet reversion in implantable ...
17481444 - Management and outcome of permanent pacemaker and implantable cardioverter-defibrillato...
19883204 - A hyaluronate-atelocollagen/beta-tricalcium phosphate-hydroxyapatite biphasic scaffold ...
23016944 - Oxygen saturation of healthy term neonates during the first 30 minutes of life.
18265674 - Long-term follow-up of a pouching operation after pancreaticoduodenectomy using a doubl...
17168984 - Study of 24 cases with congenital esophageal atresia: what are the risk factors?
Publication Detail:
Type:  Journal Article; Review     Date:  2006-04-12
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  29     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-28     Completed Date:  2006-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  666-73; discussion 673-4     Citation Subset:  IM    
Section of Cardiothoracic Surgery, James W. Riley Hospital for Children, Indiana University School of Medicine, 545 Barnhill Dr., EH 215, Indianapolis, IN 46202-5123, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aorta, Thoracic / abnormalities*,  surgery*
Follow-Up Studies
Heart Defects, Congenital / surgery*
Heart Septal Defects, Ventricular / surgery
Infant, Newborn
Survival Analysis
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease.
Next Document:  Effects of purified poloxamer 407 gel on vascular occlusion and the coronary endothelium.