Document Detail


Outcomes in patients with Goodpasture's syndrome and hydrocarbon exposure.
MedLine Citation:
PMID:  12380899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Goodpasture's Syndrome has been associated with hydrocarbon exposure. No study has examined outcomes in these patients. All reported cases of Goodpasture's Syndrome and hydrocarbon exposure were identified using MEDLINE and was analyzed for factors related to outcomes. A total of 43 cases were identified since 1969. The mean age of patients was 28 years old. There was a slight predilection for males (60%) when analyzing gender. Various types of hydrocarbons were identified and the duration of exposure varied from minutes to years. A majority of patients (86%) had pulmonary hemorrhage and antiglomerular basement membrane antibodies (AGBM) (92%). Patients were treated with immunosuppressive agents. The only significant statistical correlation was female patients with hydrocarbon exposure were younger. There was no correlation between age, gender, duration of exposure, presence of pulmonary hemorrhage or AGBM, or other risk factors and outcome. The relationship between hydrocarbon exposure and Goodpasture's Syndrome remains unclear since only 6% of cases in the literature had exposure. Even though most patients survived, no factor studied affected outcome making it difficult to predict prognosis in these patients.
Authors:
Mrugeshkumar K Shah
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Renal failure     Volume:  24     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-16     Completed Date:  2003-02-25     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  545-55     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70012, USA. mrugshah@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Glomerular Basement Membrane Disease / chemically induced*,  therapy*
Female
Humans
Hydrocarbons / adverse effects*
Infant
Male
Middle Aged
Outcome Assessment (Health Care)*
Chemical
Reg. No./Substance:
0/Hydrocarbons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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