| Outcomes in patients with early-stage hypopharyngeal cancer treated with radiotherapy. | |
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MedLine Citation:
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PMID: 19910141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To analyze the outcome in patients with early-stage hypopharyngeal cancer (HPC) who were treated with radiotherapy (RT). METHODS AND MATERIALS: Between February 1988 and February 2007, 77 patients with Stage I or Stage II HPC underwent definitive RT in the Division of Radiation Oncology at the National Cancer Center Hospital. Eleven of the patients received local irradiation, and the other 66 patients received elective bilateral neck irradiation and booster irradiation to the primary lesion. The median follow-up period for all the patients was 33 months from the start of RT, ranging from 3 to 229 months. RESULTS: The rates of overall survival, HPC-specific survival, HPC recurrence-free survival, and local control with laryngeal voice preservation for the 77 patients at 5 years were 47%, 74%, 57%, and 70%, respectively. The survival rates were not affected by the patient characteristics or treatment factors, but the RT field was significantly correlated with local control in a multivariate analysis. Seven of the patients had Grade 3 or greater complications, but these complications occurred after salvage surgery in 6 of the patients. Of the 77 patients, 83% had synchronous or metachronous malignancies, but these malignancies did not influence the survival of the patients if the malignancies were detected at an early stage. CONCLUSION: RT is an appropriate treatment method for early-stage HPC. However, because synchronous or metachronous malignancies occur at a relatively high frequency, careful follow-up and the early detection of such malignancies are critical. |
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Authors:
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Ryo-ichi Yoshimura; Yoshikazu Kagami; Yoshinori Ito; Masao Asai; Hiroshi Mayahara; Minako Sumi; Jun Itami |
Publication Detail:
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Type: Journal Article Date: 2009-11-10 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 77 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 1017-23 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan. ysmrmrad@tmd.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / therapeutic use Carcinoma, Squamous Cell / mortality, pathology, radiotherapy*, surgery Disease-Free Survival Female Follow-Up Studies Humans Hypopharyngeal Neoplasms / mortality, pathology, radiotherapy*, surgery Male Middle Aged Neoplasm Recurrence, Local / mortality, surgery Neoplasm Staging Neoplasms, Multiple Primary / drug therapy, mortality Radiotherapy Dosage Salvage Therapy Survival Rate Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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