| Outcomes of high-order multiple implantations in women undergoing ovum donation. | |
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MedLine Citation:
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PMID: 9360184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing numbers of young women with ovarian failure and women of advanced reproductive age (> 40 yrs) utilize oocyte donation to treat their infertility. In both groups, women who become pregnant frequently experience multiple gestation, occurring in up to 30% of pregnancies. Advanced maternal age and high-order multiple gestations are associated with an increased risk for obstetric complications. We reviewed the pregnancies of patients with high-order multiple gestations (> or = 3 gestational sacs) with respect to their antepartum course and neonatal outcomes. Mothers were divided into two groups according to age at conception; Group I (> or = 40 yr, n = 20) and Group II (< 40 yr, n = 10). These 30 high-order multiple gestations were found among 127 successful oocyte donation cycles (23.6% of all pregnant patients). Data regarding pregnancy outcomes were gained by chart review and telephone interview. Results demonstrated spontaneous reductions in the number of implantation sites were similar between groups (Group I: 21.4% vs. Group II: 17.6%). Multifetal pregnancy reduction (MFPR) was more often chosen by older women (Group I: 45% vs. Group II: 10%; P < 0.05). Antenatal complications were commonly experienced by both groups (> 80%) as were operative deliveries (> 85%). However, neonatal outcomes were generally good, with only one death occurring in the 79 delivered infants (1.3%). We conclude transferring supernumerary embryos to women undergoing ovum donation places patients at great risk for high-order multiple gestations. These pregnancies are associated with increased antenatal and neonatal complications. Although advanced maternal age is normally an added risk factor, well-screened older patients carrying high-order multiple gestations experienced similar outcomes as younger mothers. |
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Authors:
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T B Koopersmith; S R Lindheim; R A Lobo; R J Paulson; M V Sauer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of maternal-fetal medicine Volume: 6 ISSN: 1057-0802 ISO Abbreviation: J Matern Fetal Med Publication Date: 1997 Sep-Oct |
Date Detail:
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Created Date: 1997-12-11 Completed Date: 1997-12-11 Revised Date: 2004-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9211288 Medline TA: J Matern Fetal Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 268-72 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Embryo Implantation* Embryo Transfer Female Fertilization in Vitro Gestational Age Humans Infertility, Female / therapy* Maternal Age Middle Aged Oocyte Donation* Pregnancy Pregnancy Outcome Pregnancy Reduction, Multifetal Pregnancy, High-Risk Pregnancy, Multiple Retrospective Studies Treatment Outcome* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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