Document Detail

Outcomes of extremely preterm infants following severe intracranial hemorrhage.
MedLine Citation:
PMID:  24370654     Owner:  NLM     Status:  Publisher    
Objective:Severe intracranial hemorrhage (ICH) is an important prognostic variable in extremely preterm (EPT) infants. We examined imaging and clinical variables that predict outcomes in EPT infants with severe ICH.Study design:Retrospective analysis of 353 EPT infants with severe ICH. Outcomes were compared by examining: (i) unilateral vs bilateral ICH; and (ii) presence vs absence of hemorrhagic parenchymal infarction (HPI). Regression analyses identified variables associated with death or neurodevelopmental impairment (NDI).Result:Bilateral ICH and HPI had higher rates of adverse outcomes and were independently associated with death/NDI. HPI was the most important variable for infants of lower birth weight, and bilateral ICH for larger infants. For infants surviving to 36 weeks, shunt placement was most associated with death/NDI.Conclusion:Bilateral ICH and the presence of HPI in EPT infants with severe ICH are associated with death/NDI, though the importance depends on birth weight and survival to 36 weeks.Journal of Perinatology advance online publication, 26 December 2013; doi:10.1038/jp.2013.162.
A S Davis; S R Hintz; R F Goldstein; N Ambalavanan; C M Bann; B J Stoll; E F Bell; S Shankaran; A R Laptook; M C Walsh; E C Hale; N S Newman; A Das; R D Higgins
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-26
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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