Document Detail


Outcomes of extremely low birth weight infants given early high-dose erythropoietin.
MedLine Citation:
PMID:  22722674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate long-term outcomes of 60 extremely low birth weight (ELBW) infants treated with or without three injections of high-dose erythropoietin (Epo).
STUDY DESIGN: A retrospective analysis of anthropometric and neurodevelopmental outcome data comparing 30 ELBW infants enrolled in a phase I/II study examining the pharmacokinetics of high-dose Epo (500, 1000 and 2500 U/kg × 3 doses) administered to 30 concurrent controls.
RESULT: Birth characteristics and growth from 4 to 36 months were similar for untreated and Epo-treated patients. Multiple linear regression analysis of neurodevelopmental follow-up scores from 17/25 Epo-treated and 18/26 control infants identified that Epo correlated with improvement of cognitive (R=0.22, P=0.044) and motor (R=0.15, P=0.026) scores. No negative long-term effects of Epo treatment were evident.
CONCLUSION: Retrospective analysis of the only available long-term follow-up data from ELBW infants given high-dose Epo treatment suggests that Epo treatment is safe and correlates with modest improvement of neurodevelopmental outcomes.
Authors:
R M McAdams; R J McPherson; D E Mayock; S E Juul
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Publication Detail:
Type:  Journal Article     Date:  2012-06-21
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  33     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-08-12     Revised Date:  2014-05-23    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain Diseases / prevention & control
Cognition Disorders / prevention & control
Developmental Disabilities / prevention & control*
Erythropoietin / administration & dosage*,  pharmacokinetics
Female
Humans
Infant, Extremely Low Birth Weight*
Infant, Newborn
Pregnancy
Pregnancy Outcome*
Retrospective Studies
Grant Support
ID/Acronym/Agency:
R01 HD052820/HD/NICHD NIH HHS; UL1 TR000423/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
11096-26-7/Erythropoietin
Comments/Corrections
Comment In:
J Perinatol. 2013 May;33(5):411   [PMID:  23624973 ]
J Perinatol. 2013 May;33(5):412   [PMID:  23624974 ]

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