Document Detail


Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition.
MedLine Citation:
PMID:  22236557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: We compared neurodevelopmental outcomes of extremely low birth weight (ELBW) infants with and without bronchopulmonary dysplasia (BPD), using the physiologic definition.
STUDY DESIGN: ELBW (birth weights<1000 g) infants admitted to the Neonatal Research Network centers and hospitalized at 36 weeks postmenstrual age (n=1189) were classified using the physiologic definition of BPD. Infants underwent Bayley III assessment at 18-22 months corrected age. Multivariable logistic regression was used to determine the association between physiologic BPD and cognitive impairment (score<70).
RESULTS: BPD by the physiologic definition was diagnosed in 603 (52%) infants, 537 of whom were mechanically ventilated or on FiO(2)>30% and 66 who failed the room air challenge. Infants on room air (n=505) and those who passed the room air challenge (n=51) were classified as "no BPD" (n=556). At follow up, infants with BPD had significantly lower mean weight and head circumference. Moderate to severe cerebral palsy (7 vs. 2.1%) and spastic diplegia (7.8 vs. 4.1%) and quadriplegia (3.9 vs. 0.9%) phenotypes as well as cognitive (12.8 vs. 4.6%) and language scores<70 (24.2 vs. 12.3%) were significantly more frequent in those with BPD compared to those without BPD. BPD was independently associated (adjusted OR 2.4; 95% CI 1.40-4.13) with cognitive impairment.
CONCLUSIONS: Rates of adverse neurodevelopmental outcomes in early childhood were significantly higher in those with BPD. BPD by the physiologic definition was independently associated with cognitive impairment using Bayley Scales III. These findings have implications for targeted post-discharge surveillance and early intervention.
Authors:
Girija Natarajan; Athina Pappas; Seetha Shankaran; Douglas E Kendrick; Abhik Das; Rosemary D Higgins; Abbot R Laptook; Edward F Bell; Barbara J Stoll; Nancy Newman; Ellen C Hale; Rebecca Bara; Michele C Walsh
Related Documents :
2340687 - Diseases that mimic meningitis. analysis of 650 lumbar punctures.
22748607 - Complementary feeding patterns in india.
15370087 - Hydrocephalus secondary to group b streptococcal meningitis.
9764327 - Salmonella meningitis in thai infants: clinical case reports.
1797647 - Microlevel epidemiological variations in malaria & its implications on control strategy.
18922207 - Mean length of utterance before words and grammar: longitudinal trends and developmenta...
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-10
Journal Detail:
Title:  Early human development     Volume:  88     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-10-09     Revised Date:  2014-05-01    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  509-15     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Bronchopulmonary Dysplasia / classification,  diagnosis*,  physiopathology,  therapy*
Early Medical Intervention
Educational Status
Female
Follow-Up Studies
Gestational Age
Humans
Infant, Extremely Low Birth Weight* / physiology
Infant, Newborn
Infant, Newborn, Diseases / classification,  diagnosis,  physiopathology,  therapy
Male
Prognosis
Terminology as Topic*
Treatment Outcome
Young Adult
Grant Support
ID/Acronym/Agency:
M01 RR125/RR/NCRR NIH HHS; M01 RR30/RR/NCRR NIH HHS; M01 RR32/RR/NCRR NIH HHS; M01 RR39/RR/NCRR NIH HHS; M01 RR44/RR/NCRR NIH HHS; M01 RR54/RR/NCRR NIH HHS; M01 RR59/RR/NCRR NIH HHS; M01 RR633/RR/NCRR NIH HHS; M01 RR70/RR/NCRR NIH HHS; M01 RR7122/RR/NCRR NIH HHS; M01 RR750/RR/NCRR NIH HHS; M01 RR80/RR/NCRR NIH HHS; M01 RR8084/RR/NCRR NIH HHS; M01 RR997/RR/NCRR NIH HHS; U10 HD021385-16/HD/NICHD NIH HHS; U10 HD027904-12/HD/NICHD NIH HHS; U10 HD21364/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD27851/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27856/HD/NICHD NIH HHS; U10 HD27871/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD34216/HD/NICHD NIH HHS; U10 HD36790/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS; U10 HD40492/HD/NICHD NIH HHS; U10 HD40498/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; U10 HD40689/HD/NICHD NIH HHS; U10 HD53089/HD/NICHD NIH HHS; U10 HD53119/HD/NICHD NIH HHS; U10HD53109/HD/NICHD NIH HHS; UL1 RR24139/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Physical therapy in a value-based healthcare world.
Next Document:  Radioactivity from Fukushima Dai-ichi in air over Europe; part 2: what can it tell us about the acci...