Document Detail

Outcomes of extremely low birth weight infants with varying doses and intervals of antenatal steroid exposure.
MedLine Citation:
PMID:  20297898     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare outcomes of extremely low birth weight (ELBW) infants exposed to no antenatal steroids (ANS); incomplete ANS and complete course of ANS at varying intervals prior to delivery. METHODS: A retrospective review was performed on 169 ELBW infants with ANS exposure at varied dose-intervals. The odds of mortality, intraventricular hemorrhage (IVH) and bronchopulmonary dysplasia (BPD) were compared between Group 1, infants born without ANS exposure, Group 2, infants born after one dose of ANS, Group 3, infants born after two doses of ANS given within a week, and Group 4, infants born after two doses of ANS >7 days prior to delivery. RESULTS: Mortality and IVH were significantly lower in Groups 3 (30% and 10%) and 4 (15% and 30%), compared to Groups 1 (56% and 69%) and 2 (56% and 38%). Increasing gestational age and exposure to complete course of ANS were significantly associated with decrease in mortality, BPD/mortality and IVH. Infants who received one dose of ANS had significantly lower incidence of severe IVH compared to infants without ANS exposure. CONCLUSIONS: Beneficial impact of ANS on mortality and composite BPD/mortality is evident only after a complete course and persists even with its administration beyond a week from delivery.
Sanjay Chawla; Girija Natarajan; Sharayu Rane; Ronald Thomas; Josef Cortez; Jorge Lua
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  38     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-06     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  IM    
Department of Neonatology, Wayne State University, Detroit, USA.
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MeSH Terms
Bronchopulmonary Dysplasia / epidemiology,  prevention & control
Cerebral Hemorrhage / epidemiology,  prevention & control
Cerebral Ventricles
Cohort Studies
Drug Administration Schedule
Gestational Age
Infant Mortality
Infant, Extremely Low Birth Weight*
Infant, Newborn
Michigan / epidemiology
Retrospective Studies
Steroids / administration & dosage*
Treatment Outcome
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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