Document Detail

Outcomes of early parenteral nutrition for premature infants.
MedLine Citation:
PMID:  19865093     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of early amino acid (early AA) administration in very low birth weight (VLBW) infants. STUDY DESIGN: A pre- and post-intervention study was conducted after initiating an early AA administration protocol. Clinical outcomes were collected for all VLBW infants admitted on the first day of life for 9 months before protocol initiation (standard parenteral nutrition (PN)), and 10 months after initiation of early AA. RESULT: In all, 88 infants met study criteria for standard PN, and 85 infants for early AA administration. The patient characteristics were similar between the groups. There were no differences in mortality, the day birth weight was regained, the day enteral feeds started, the duration of PN, the day full feeds achieved and weight at 32 weeks post-menstrual age. No differences were found for late sepsis, direct hyperbilirubinemia and chronic lung disease. Necrotizing enterocolitis (NEC) occurred more frequently in the early AA administration group (12 vs 1%, P=0.012). CONCLUSION: Early AA administration for VLBW infants was as efficacious as standard therapy, although increased NEC in the early AA period may have negatively affected growth and nutrition in that period.
J Trintis; P Donohue; S Aucott
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Publication Detail:
Type:  Journal Article     Date:  2009-10-29
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-7     Citation Subset:  IM    
Division of Neonatology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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MeSH Terms
Amino Acids / administration & dosage*
Case-Control Studies
Dietary Supplements
Enterocolitis, Necrotizing / etiology
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight
Parenteral Nutrition / adverse effects,  methods*
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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