| Outcomes of diabetics receiving bare-metal stents versus drug-eluting stents. | |
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MedLine Citation:
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PMID: 20882647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to determine if differences existed in in-hospital outcomes, long-term rates of target vessel revascularization (TVR), and/or long-term mortality trends between patients with diabetes mellitus undergoing percutaneous coronary intervention (PCI) with either a drug-eluting stent(s) (DES) or a bare metal stent(s) (BMS). BACKGROUND: Short- and long-term clinical outcomes of patients with diabetes mellitus undergoing PCI with DES versus BMS remain inconsistent between randomized-controlled trials (RCTs) and observational studies. METHODS: Data were collected prospectively on diabetics undergoing PCI with either DES or BMS from January 2000 to June 2008. Demographic information, medical histories, in-hospital outcomes, and long-term TVR and mortality trends were obtained for all patients. RESULTS: A total of 1,319 patients were included in the study. Diabetics receiving DES had a significant reduction in index admission MACE compared to diabetics receiving BMS. Using multivariable adjustment, after a mean follow-up of 2.5 years (maximum 5 years), diabetics who received DES had a 38% decreased risk of TVR compared to diabetics with BMS [HR 0.62 (95% CI: 0.43-0.90)]; diabetics with DES had an insignificant adjusted improvement in long-term survival compared to diabetics with BMS [HR 0.72 (95% CI: 0.52-1.00)]. These long-term survival and TVR rates were confirmed using propensity scoring. CONCLUSIONS: The use of DES when compared with BMS among diabetics undergoing PCI is associated with significant improvement in long-term TVR, with an insignificant similar trend in all-cause mortality. The long-term results of this observational study are consistent with prior RCTs after adjusting for confounding variables. |
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Authors:
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Vijay S Ramanath; Jeremiah R Brown; David J Malenka; James T DeVries; Mandeep S Sidhu; John F Robb; John E Jayne; Bruce D Hettleman; Bruce J Friedman; Nathaniel W Niles; Aaron V Kaplan; Craig A Thompson; |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 76 ISSN: 1522-726X ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 473-81 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. |
Affiliation:
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Section of Cardiology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon, Coronary / adverse effects, instrumentation*, mortality Diabetes Mellitus, Type 1 / complications*, mortality Diabetes Mellitus, Type 2 / complications*, mortality Drug-Eluting Stents* Female Heart Diseases / complications, mortality, therapy* Humans Kaplan-Meier Estimate Logistic Models Male Metals* Middle Aged New England Propensity Score Proportional Hazards Models Prospective Studies Prosthesis Design Registries Risk Assessment Risk Factors Stents* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Metals |
| Comments/Corrections | |
Comment In:
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Catheter Cardiovasc Interv. 2010 Oct 1;76(4):482-3
[PMID:
20882648
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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