| Outcomes of day 3 embryo transfer with vitrification using Cryoleaf: a 3-year follow-up study. | |
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MedLine Citation:
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PMID: 22684538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare success rates of vitrified-warmed with fresh and frozen-thawed ETs DESIGN: Retrospective. SETTING: Public fertility center. PATIENT(S): Cryopreserved- thawed/warmed ETs were included in this study. Fresh cycles, in which supernumerary embryos were cryopreserved, were set as the fresh control group. INTERVENTION(S): Supernumerary day 3 embryos were cryopreserved by slow-freezing or vitrification and transferred after thawing or warming. MAIN OUTCOME MEASURE(S): Comparison of two cryopreservation techniques with respect to post-thaw survival of embryos, implantation and pregnancy rates, neonatal outcome, and congenital birth defects. RESULTS: A total of 962 fresh, 151 freezing-thawed and 300 vitrified-warmed cycles were included in this study. The survival and intact cell rates in the vitrification group were significantly higher compared with those in the slow freezing group (88.5 % vs 74.5 % and 86.6 % vs 64.0 %). The implantation, clinical pregnancy and live birth rates of the vitrification group were similar to the fresh and significant higher than slow freezing group. There were no significant differences in mean gestational age, birth weight, stillbirth, birth defects and the prevalence of neonatal diseases among three groups. CONCLUSION: Vitrified-warmed ETs yield comparable outcomes with fresh ETs and is superior to frozen-thawed ETs regarding the survival rate and clinical outcomes. |
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Authors:
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Xing-ling Wang; Xiao Zhang; Yao-qin Qin; Da-yong Hao; Hui-rong Shi |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2012-06-10 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 29 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-10-11 Completed Date: 2013-03-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
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Languages: eng Pagination: 883-9 Citation Subset: IM |
Affiliation:
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Department of gynecology, the first affiliated hospital of Zhengzhou University, Zheng Zhou, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight Congenital Abnormalities Cryopreservation / methods* Embryo Implantation Embryo Transfer / methods* Female Follow-Up Studies Gestational Age Humans Infant, Newborn Oocyte Retrieval Ovulation Induction Pregnancy Pregnancy Outcome* Pregnancy Rate Prevalence Retrospective Studies Sperm Injections, Intracytoplasmic Vitrification* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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