Document Detail


Outcomes of day 3 embryo transfer with vitrification using Cryoleaf: a 3-year follow-up study.
MedLine Citation:
PMID:  22684538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare success rates of vitrified-warmed with fresh and frozen-thawed ETs
DESIGN: Retrospective.
SETTING: Public fertility center.
PATIENT(S): Cryopreserved- thawed/warmed ETs were included in this study. Fresh cycles, in which supernumerary embryos were cryopreserved, were set as the fresh control group.
INTERVENTION(S): Supernumerary day 3 embryos were cryopreserved by slow-freezing or vitrification and transferred after thawing or warming.
MAIN OUTCOME MEASURE(S): Comparison of two cryopreservation techniques with respect to post-thaw survival of embryos, implantation and pregnancy rates, neonatal outcome, and congenital birth defects.
RESULTS: A total of 962 fresh, 151 freezing-thawed and 300 vitrified-warmed cycles were included in this study. The survival and intact cell rates in the vitrification group were significantly higher compared with those in the slow freezing group (88.5 % vs 74.5 % and 86.6 % vs 64.0 %). The implantation, clinical pregnancy and live birth rates of the vitrification group were similar to the fresh and significant higher than slow freezing group. There were no significant differences in mean gestational age, birth weight, stillbirth, birth defects and the prevalence of neonatal diseases among three groups.
CONCLUSION: Vitrified-warmed ETs yield comparable outcomes with fresh ETs and is superior to frozen-thawed ETs regarding the survival rate and clinical outcomes.
Authors:
Xing-ling Wang; Xiao Zhang; Yao-qin Qin; Da-yong Hao; Hui-rong Shi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-06-10
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2013-03-11     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  883-9     Citation Subset:  IM    
Affiliation:
Department of gynecology, the first affiliated hospital of Zhengzhou University, Zheng Zhou, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Congenital Abnormalities
Cryopreservation / methods*
Embryo Implantation
Embryo Transfer / methods*
Female
Follow-Up Studies
Gestational Age
Humans
Infant, Newborn
Oocyte Retrieval
Ovulation Induction
Pregnancy
Pregnancy Outcome*
Pregnancy Rate
Prevalence
Retrospective Studies
Sperm Injections, Intracytoplasmic
Vitrification*
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