Document Detail

Outcomes associated with transdermal nicotine replacement therapy in a neurosurgery intensive care unit.
MedLine Citation:
PMID:  20689126     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The outcomes associated with transdermal nicotine replacement therapy (NRT) in a neurosurgery intensive care unit (ICU) were studied.
METHODS: Data from pharmacy records, neurosurgery ICU admission logs, and computerized patient charts at the University of Illinois Medical Center at Chicago from January 2001 through August 2008 were reviewed for patients older than 18 years who were admitted to the neurosurgery ICU for neurologic insults. Patients were categorized into three groups: smokers who received transdermal NRT (n = 114), smokers who did not receive transdermal NRT (n = 113), and nonsmokers (n = 113). The primary outcome of this study was unfavorable disposition at discharge from the hospital. Secondary outcomes measured included overall mortality; lengths of hospital and neurosurgery ICU stays; and rates of subarachnoid hemorrhage (SAH) rebleeding, angiographic vasospasm, intracerebral hemorrhage rebleeding, and ischemic stroke.
RESULTS: Overall, there was no difference in unfavorable discharge disposition among the three groups (p = 0.17). However, the group who received NRT had higher admission rates of SAH, smoked more cigarettes for a longer period of time, and had longer stays in the neurosurgery ICU and hospital compared with the other groups. All patients who received NRT had prolonged hospital (p = 0.014) and neurosurgery ICU (p = 0.006) stays compared with those who did not receive NRT. There were no differences in other secondary outcomes among the groups.
CONCLUSION: There was no significant difference in unfavorable discharge disposition among neurosurgery ICU patients who were smokers treated with NRT, smokers not treated with NRT, and nonsmokers not treated with NRT.
Nicholas G Panos; Eljim P Tesoro; Keri S Kim; Jeffrey J Mucksavage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists     Volume:  67     ISSN:  1535-2900     ISO Abbreviation:  Am J Health Syst Pharm     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-06     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503023     Medline TA:  Am J Health Syst Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1357-61     Citation Subset:  IM    
Department of Pharmacy Services, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA.
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MeSH Terms
Hospital Mortality
Intensive Care Units
Intracranial Hemorrhages / therapy
Middle Aged
Neurosurgical Procedures
Nicotine / administration & dosage*,  adverse effects
Nicotinic Agonists / administration & dosage,  adverse effects
Retrospective Studies
Smoking / drug therapy*
Transdermal Patch
Trauma, Nervous System / therapy
Treatment Outcome
Reg. No./Substance:
0/Nicotinic Agonists; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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