| Outcomes associated with transdermal nicotine replacement therapy in a neurosurgery intensive care unit. | |
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MedLine Citation:
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PMID: 20689126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The outcomes associated with transdermal nicotine replacement therapy (NRT) in a neurosurgery intensive care unit (ICU) were studied. METHODS: Data from pharmacy records, neurosurgery ICU admission logs, and computerized patient charts at the University of Illinois Medical Center at Chicago from January 2001 through August 2008 were reviewed for patients older than 18 years who were admitted to the neurosurgery ICU for neurologic insults. Patients were categorized into three groups: smokers who received transdermal NRT (n = 114), smokers who did not receive transdermal NRT (n = 113), and nonsmokers (n = 113). The primary outcome of this study was unfavorable disposition at discharge from the hospital. Secondary outcomes measured included overall mortality; lengths of hospital and neurosurgery ICU stays; and rates of subarachnoid hemorrhage (SAH) rebleeding, angiographic vasospasm, intracerebral hemorrhage rebleeding, and ischemic stroke. RESULTS: Overall, there was no difference in unfavorable discharge disposition among the three groups (p = 0.17). However, the group who received NRT had higher admission rates of SAH, smoked more cigarettes for a longer period of time, and had longer stays in the neurosurgery ICU and hospital compared with the other groups. All patients who received NRT had prolonged hospital (p = 0.014) and neurosurgery ICU (p = 0.006) stays compared with those who did not receive NRT. There were no differences in other secondary outcomes among the groups. CONCLUSION: There was no significant difference in unfavorable discharge disposition among neurosurgery ICU patients who were smokers treated with NRT, smokers not treated with NRT, and nonsmokers not treated with NRT. |
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Authors:
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Nicholas G Panos; Eljim P Tesoro; Keri S Kim; Jeffrey J Mucksavage |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists Volume: 67 ISSN: 1535-2900 ISO Abbreviation: Am J Health Syst Pharm Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-06 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503023 Medline TA: Am J Health Syst Pharm Country: United States |
Other Details:
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Languages: eng Pagination: 1357-61 Citation Subset: IM |
Affiliation:
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Department of Pharmacy Services, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA. npanos@lumc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chicago Female Hospital Mortality Humans Intensive Care Units Intracranial Hemorrhages / therapy Male Middle Aged Neurosurgical Procedures Nicotine / administration & dosage*, adverse effects Nicotinic Agonists / administration & dosage, adverse effects Retrospective Studies Smoking / drug therapy* Transdermal Patch Trauma, Nervous System / therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Nicotinic Agonists; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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