| Outcomes after esophagectomy: a ten-year prospective cohort. | |
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MedLine Citation:
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PMID: 12537219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The Department of Veterans Affairs National Surgical Quality Improvement Program is a unique resource to prospectively analyze surgical outcomes from a cross-section of surgical services nationally. We used this database to assess risk factors for morbidity and mortality after esophagectomy in Veterans Affairs Medical Centers from 1991 to 2001. METHODS: A total of 1,777 patients underwent an esophagectomy at 109 Veterans Affairs hospitals with complete in-hospital and 30-day outcomes recorded. Bivariate and multivariable analyses were completed. RESULTS: Thirty-day mortality was 9.8% (174/1,777) and the incidence of one or more of 20 predefined complications was 49.5% (880/1,777). The most frequent postoperative complications were pneumonia in 21% (380/1,777), respiratory failure in 16% (288/1,777), and ventilator support more than 48 hours in 22% (387/1,777). Preoperative predictors of mortality based on multivariable analysis included neoadjuvant therapy, blood urea nitrogen level of more than 40 mg/dL, alkaline phosphatase level of more than 125 U/L, diabetes mellitus, alcohol abuse, decreased functional status, ascites, and increasing age. Preoperative factors impacting morbidity were increasing age, dyspnea, diabetes mellitus, chronic obstructive pulmonary disease, alkaline phosphatase level of more than 125 U/L, lower serum albumin concentration, increased complexity score, and decreased functional status. Intraoperative risk factors for mortality included the need for transfusion; intraoperative risk factors for morbidity included the need for transfusion and longer operative time. CONCLUSIONS: These data constitute the largest prospective outcomes cohort in the literature and document a near 50% morbidity rate and 10% mortality rate after esophagectomy. Data from this study can be used to better stratify patients before esophagectomy. |
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Authors:
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Stephen H Bailey; David A Bull; David H Harpole; Jeffrey J Rentz; Leigh A Neumayer; Theodore N Pappas; Jennifer Daley; William G Henderson; Barbara Krasnicka; Shukri F Khuri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 75 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-22 Completed Date: 2003-02-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: United States |
Other Details:
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Languages: eng Pagination: 217-22; discussion 222 Citation Subset: AIM; IM |
Affiliation:
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Veterans Affairs Medical Center, University of Utah Medical School, Salt Lake City, Utah 84132, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Alcoholism / complications Alkaline Phosphatase / blood Ascites / complications Blood Urea Nitrogen Cohort Studies Diabetes Complications Dyspnea / complications Esophagectomy* / mortality Female Humans Male Middle Aged Multivariate Analysis Pneumonia / etiology Postoperative Complications Prospective Studies Pulmonary Disease, Chronic Obstructive / complications Respiratory Insufficiency / etiology Risk Factors Serum Albumin / analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; EC 3.1.3.1/Alkaline Phosphatase |
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