Document Detail


Outcomes and milestone achievement differences for very low-birth-weight multiples compared with singleton infants.
MedLine Citation:
PMID:  20119891     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined if very low-birth-weight (VLBW) infants of multiple gestation pregnancies experience more complications and take longer to achieve clinical milestones compared with similar singletons. We performed a retrospective analysis of all infants less than 1500 g at birth in a large neonatal database. Singletons were compared with twins and higher-order multiples for demographic, morbidities, and process milestones including feeding, respiratory, thermoregulation, and length of stay. Multivariable regression analyses were performed to control for potential confounding variables. A total of 5507 infants were included: 3792 singletons, 1391 twins, and 324 higher-order multiples. There were no differences in Apgar scores, small for gestational age status, and incidence of necrotizing enterocolitis, severe retinopathy of prematurity, severe intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, or the need for surgery. Multiples had higher rates of apnea and patent ductus arteriosus than singletons. VLBW multiples achieved milestones at similar rates in most areas compared with singletons except for the achievement of full oral feedings. Length of stay, after controlling for confounding variables, did not differ between the groups. Compared with singletons, VLBW multiples had similar morbidity and achieved most feeding and thermoregulation milestones at similar rates.
Authors:
Sharon Kirkby; Linda Genen; Wendy Turenne; Kevin Dysart
Publication Detail:
Type:  Journal Article     Date:  2010-01-29
Journal Detail:
Title:  American journal of perinatology     Volume:  27     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Copyright Information:
Thieme Medical Publishers.
Affiliation:
NICU Clinical Research and Data Management, Atlanta, Georgia 30339, USA. sharon.kirkby@alere.com
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MeSH Terms
Descriptor/Qualifier:
Female
Gestational Age
Humans
Infant Mortality*
Infant, Newborn
Infant, Premature, Diseases / mortality*
Infant, Very Low Birth Weight*
Male
Pregnancy
Pregnancy, Multiple
Retrospective Studies

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