| Outcomes of birdshot chorioretinopathy treated with an intravitreal sustained-release fluocinolone acetonide-containing device. | |
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MedLine Citation:
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PMID: 21277557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate outcomes in birdshot chorioretinopathy following intravitreal implantation of a fluocinolone acetonide-containing drug delivery device. DESIGN: Retrospective, multicenter, interventional case study. METHODS: University- and community-based tertiary care. Twenty-two HLA-A29+ birdshot patients (36 eyes) were implanted with a sustained-release corticosteroid device and followed for up to 3 years. Main outcome measures were Snellen acuity, intraocular inflammation, adjunctive therapy, cataract, ocular hypertension, or glaucoma. Paired Wilcoxon statistics were used to analyze visual acuities; paired McNemar statistics were used to analyze presence or absence of other outcomes. RESULTS: Nineteen of 22 patients (32 eyes) completed 12 months of follow-up with improvement in median visual acuity (P=.015). Prior to implantation, 18 of 22 patients (82%) received immunosuppressive therapy versus 1 of 19 (5%) by 12 months (P<.001). Eyes with zero vitreous haze increased from 7 of 27 scored eyes (26%) at baseline to 30 of 30 eyes (100%) by 12 months (P<.001). Cystoid macular edema decreased from 13 of 36 eyes (36%) at baseline to 2 of 32 eyes (6%) at 12 months (P=.006). Five of 24 phakic eyes at baseline exited the study before surgery; all other eyes received cataract surgery. One hundred percent of study eyes had ocular hypertension, required intraocular pressure-lowering therapy, or had glaucoma surgery by 12 months. CONCLUSIONS: Implantation of a fluocinolone acetonide-containing intraocular device in birdshot chorioretinopathy can improve vision, control inflammation, and eliminate systemic therapy. There is a high incidence of cataract progression and intraocular hypertension or glaucoma. |
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Authors:
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Ryan B Rush; Debra A Goldstein; David G Callanan; Beeran Meghpara; William J Feuer; Janet L Davis |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-01 |
Journal Detail:
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Title: American journal of ophthalmology Volume: 151 ISSN: 1879-1891 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-05-06 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 630-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cataract / physiopathology Choroid Diseases / drug therapy*, physiopathology Drug Delivery Systems* Drug Implants Electroretinography Female Fluorescein Angiography Humans Male Middle Aged Pregnadienetriols / administration & dosage*, adverse effects Retinal Diseases / drug therapy*, physiopathology Retrospective Studies Treatment Outcome Visual Acuity / physiology Visual Fields Vitreous Body |
| Grant Support | |
ID/Acronym/Agency:
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P30 EY001792/EY/NEI NIH HHS; P30 EY001792/EY/NEI NIH HHS; P30 EY001792-33/EY/NEI NIH HHS; P30 EY014801/EY/NEI NIH HHS; P30 EY014801/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drug Implants; 0/Pregnadienetriols; 3693-39-8/flucloronide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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