Document Detail


Outcomes Among hypertensive patients with concomitant peripheral and coronary artery disease: findings from the INternational VErapamil-SR/Trandolapril STudy.
MedLine Citation:
PMID:  19996066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is a common risk factor for peripheral arterial disease (PAD). Guidelines suggest treating PAD patients to a blood pressure <130/80 mm Hg; therefore, our objective was to explore whether attainment of this target blood pressure is associated with improved outcomes. We performed a post hoc analysis of the INternational VErapamil-SR/Trandolapril STudy, a randomized clinical trial, which included hypertensive patients with concomitant PAD and coronary artery disease. There were 2699 PAD patients followed for a mean of 2.7 years (60 970 patient-years). The primary outcome, all-cause death, nonfatal myocardial infarction, or nonfatal stroke, occurred in 16.3% of PAD patients versus 9.2% without PAD (adjusted hazard ratio: 1.26 [95% CI: 1.13 to 1.40]; P<0.0001). The primary outcome occurred least frequently among PAD patients treated to an average systolic blood pressure of 135 to 145 mm Hg and an average diastolic blood pressure of 60 to 90 mm Hg. PAD patients displayed a J-shape relationship with systolic blood pressure and the primary outcome, although individuals without PAD did not. PAD patients may require a different target blood pressure than those without PAD.
Authors:
Anthony A Bavry; R David Anderson; Yan Gong; Scott J Denardo; Rhonda M Cooper-Dehoff; Eileen M Handberg; Carl J Pepine
Related Documents :
19770736 - Antihypertensive treatment of acute cerebral hemorrhage.
23278596 - Impact of stepwise hyperventilation on cerebral tissue oxygen saturation in anesthetize...
2889416 - Ibuprofen interferes with the efficacy of antihypertensive drugs. a randomized, double-...
18656 - Changes in blood pressure and antihypertensive treatment in a community over four years.
15563576 - Effects of chronic baroreceptor unloading on blood pressure in the dog.
1456556 - Effects of repetitive airway obstruction on o2 saturation and systemic and pulmonary ar...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-07
Journal Detail:
Title:  Hypertension     Volume:  55     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-01-21     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  48-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
Aged
Angiotensin II Type 1 Receptor Blockers / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antihypertensive Agents / therapeutic use*
Aspirin / therapeutic use
Blood Pressure / drug effects*
Coronary Artery Disease / complications*
Female
Follow-Up Studies
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hypertension / complications,  drug therapy*,  physiopathology
Kaplan-Meier Estimate
Male
Multicenter Studies as Topic
Outcome Assessment (Health Care) / methods,  statistics & numerical data
Peripheral Vascular Diseases / complications*
Randomized Controlled Trials as Topic
Grant Support
ID/Acronym/Agency:
K23 HL086558/HL/NHLBI NIH HHS; K23 HL086558-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; R16CO5Y76E/Aspirin
Comments/Corrections
Comment In:
Curr Hypertens Rep. 2010 Apr;12(2):53-5   [PMID:  20424956 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis...
Next Document:  Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with di...