| Outcome of very low birth weight infants exposed to antenatal indomethacin for tocolysis. | |
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MedLine Citation:
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PMID: 15861198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Beginning in October 1995, and for several years thereafter, our institution used indomethacin as a first-line tocolytic drug. Our purpose is to compare the outcomes of very low birth weight infants who were exposed to antenatal indomethacin with those who were not exposed to this therapy. STUDY DESIGN: We used our center's component of the NICHD Neonatal Research Network's Generic Data Base which recorded the outcomes of all live born infants weighing less than 1500 g over a 5-year period. We abstracted data concerning neonatal morbidity (death, Grades III to IV intraventricular hemorrhage (IVH), necrotizing enterocolitis and patent ductus arteriosus), as well as other factors including gestational age, birth weight, antenatal corticosteroid treatment and maternal hypertension or pre-eclampsia. Univariate analysis was performed using Fisher's exact test. Multivariate analysis using logistic regression was performed to control for confounding factors. RESULTS: A total of 85 infants who were exposed to antenatal indomethacin were compared to 464 infants who were not exposed to the drug. In the univariate analysis, antenatal indomethacin exposure was not associated with a significant increase in the incidence of necrotizing enterocolitis or patent ductus arteriosus. The incidence of Grades III to IV IVH was 17.9% in those infants exposed to antenatal indomethacin compared to 7.1% in the nonexposed infants (p=0.008). The incidence of neonatal death in the exposed infants was 27.7 versus 16.4 in the nonexposed infants (p=0.02). After controlling for antenatal corticosteroids, maternal pre-eclampsia, gestational age and birth weight, antenatal indomethacin was significantly associated with an increased incidence of IVH, but not neonatal death. CONCLUSION: Antenatal indomethacin was associated with significantly higher rates of IVH. Additional studies assessing the potential risks of indomethacin tocolysis are needed before it is used as a first-line tocolytic therapy. |
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Authors:
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Nora M Doyle; Michael O Gardner; Lorraine Wells; Clifford Qualls; Lu-Ann Papile |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 25 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-29 Completed Date: 2005-08-30 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 336-40 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Division of Maternal Fetal Medicine, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cause of Death* Cohort Studies Critical Care Ductus Arteriosus, Patent / chemically induced, mortality, physiopathology Enterocolitis, Necrotizing / chemically induced, mortality, physiopathology Female Follow-Up Studies Humans Indomethacin / adverse effects*, therapeutic use Infant, Newborn Infant, Premature, Diseases / chemically induced*, mortality*, physiopathology Infant, Very Low Birth Weight* Intensive Care Units, Neonatal Intracranial Hemorrhages / chemically induced, mortality, physiopathology Logistic Models Male Pregnancy Prenatal Exposure Delayed Effects* Probability Retrospective Studies Risk Assessment Severity of Illness Index Survival Rate Tocolysis / adverse effects |
| Chemical | |
Reg. No./Substance:
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53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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