Document Detail

Outcome of vancomycin treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia.
MedLine Citation:
PMID:  17984229     Owner:  NLM     Status:  MEDLINE    
Limited data on the clinical outcome of vancomycin treatment compared with that of beta-lactam treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia (MSSA-B) are available. We used different and complementary approaches: (i) a retrospective cohort study using a propensity score to adjust for confounding by treatment assignment and (ii) a matched case-control study. Of all patients with S. aureus bacteremia (SAB) in two university-affiliated hospitals over a 7-year period, 294 patients with MSSA-B were enrolled in the cohort study. The cases for the case-control study were defined as patients who received vancomycin treatment for MSSA-B; the controls, who were patients that received beta-lactam treatment for MSSA-B, were selected at a 1:2 (case:control) ratio according to the objective matching scoring system and the propensity score system. In the cohort study, SAB-related mortality in patients with vancomycin treatment (37%, 10/27) was significantly higher than that in those with beta-lactam treatment (18%, 47/267) (P = 0.02). In addition, multivariate analysis revealed that vancomycin treatment was associated with SAB-related mortality when independent predictors for SAB-related mortality and propensity score were considered (adjusted odds ratio of 3.3, 95% confidence interval of 1.2 to 9.5). In the case-control study using the objective matching scoring system and the propensity score system, SAB-related mortality in case patients was 37% (10/27) and in control patients 11% (6/54) (P < 0.01). Our data suggest that vancomycin is inferior to beta-lactam in the treatment of MSSA-B.
Sung-Han Kim; Kye-Hyung Kim; Hong-Bin Kim; Nam-Joong Kim; Eui-Chong Kim; Myoung-don Oh; Kang-Won Choe
Related Documents :
8712519 - Efficacy of florfenicol for treatment of clinical and subclinical bovine mastitis.
6352619 - Open study of ceftazidime in serious infections due to multiply-resistant bacteria.
24432289 - Errata.
23988129 - Preoperative atrial fibrillation and long-term survival after open heart surgery in a r...
18680179 - Good effect of igy against pseudomonas aeruginosa infections in cystic fibrosis patients.
8882529 - Evaluation of the efficacy of sequential intravenous-oral administration of pefloxacin ...
24165669 - A prospective clinical study of flow-mediated dilatation in burn injury.
22048089 - Arthroscopic rotator cuff repair with and without acromioplasty in the treatment of ful...
18520869 - Psychological considerations of the bariatric surgery patient undergoing body contourin...
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-11-05
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  52     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-31     Completed Date:  2008-05-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
Department of Internal Medicine, Seoul National University College of Medicine, 28 Youngundong, Chongrogu, Seoul 110-744, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Bacterial Agents / pharmacology*,  therapeutic use*
Bacteremia / drug therapy*,  microbiology,  mortality
Case-Control Studies
Cohort Studies
Hospitals, University
Methicillin / pharmacology*,  therapeutic use
Microbial Sensitivity Tests
Middle Aged
Staphylococcal Infections / drug therapy,  microbiology,  mortality
Staphylococcus aureus / drug effects*
Treatment Outcome
Vancomycin / therapeutic use*
beta-Lactams / pharmacology,  therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/beta-Lactams; 1404-90-6/Vancomycin; 61-32-5/Methicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparative genome analysis across a kingdom of eukaryotic organisms: specialization and diversifica...
Next Document:  Hepatitis B virus e antigen loss during adefovir dipivoxil therapy is associated with enhanced virus...