Document Detail


Outcome of transplantation for myelofibrosis.
MedLine Citation:
PMID:  19879949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myelofibrosis is a myeloproliferative disorder incurable with conventional strategies. Several small series have reported long-term disease-free survival (DSF) after allogeneic hematopoietic cell transplantation (HCT). In this study, we analyze the outcomes of 289 patients receiving allogeneic transplantation for primary myelofibrosis between 1989 and 2002, from the database of the Center for International Bone Marrow Transplant Research (CIBMTR). The median age was 47 years (range: 18-73 years). Donors were HLA identical siblings in 162 patients, unrelated individuals in 101 patients, and HLA nonidentical family members in 26 patients. Patients were treated with a variety of conditioning regimens and graft-versus-host disease (GVHD) prophylaxis regimens. Splenectomy was performed in 65 patients prior to transplantation. The 100-day treatment-related mortality was 18% for HLA identical sibling transplants, 35% for unrelated transplants, and 19% for transplants from alternative related donors. Corresponding 5-year overall survival (OS) rates were 37%, 30%, and 40%, respectively. DFS rates were 33%, 27%, and 22%, respectively. DFS for patients receiving reduced-intensity transplants was comparable: 39% for HLA identical sibling donors and 17% for unrelated donors at 3 years. In this large retrospective series, allogeneic transplantation for myelofibrosis resulted in long-term relapse-free survival (RFS) in about one-third of patients.
Authors:
Karen K Ballen; Smriti Shrestha; Kathleen A Sobocinski; Mei-Jie Zhang; Asad Bashey; Brian J Bolwell; Francisco Cervantes; Steven M Devine; Robert Peter Gale; Vikas Gupta; Theresa E Hahn; William J Hogan; Nicolaus Kröger; Mark R Litzow; David I Marks; Richard T Maziarz; Philip L McCarthy; Gary Schiller; Harry C Schouten; Vivek Roy; Peter H Wiernik; Mary M Horowitz; Sergio A Giralt; Mukta Arora
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2009-10-30
Journal Detail:
Title:  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation     Volume:  16     ISSN:  1523-6536     ISO Abbreviation:  Biol. Blood Marrow Transplant.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-05-28     Revised Date:  2014-06-10    
Medline Journal Info:
Nlm Unique ID:  9600628     Medline TA:  Biol Blood Marrow Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-67     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Disease-Free Survival
Female
Graft Rejection / epidemiology
Graft Survival
Graft vs Host Disease / mortality
Hematopoietic Stem Cell Transplantation / mortality*
Histocompatibility / genetics
Humans
Kaplan-Meier Estimate
Karnofsky Performance Status
Male
Middle Aged
Postoperative Complications / mortality
Primary Myelofibrosis / mortality*,  therapy*
Recurrence
Retrospective Studies
Risk Factors
Siblings
Splenomegaly
Transplantation Conditioning / methods,  statistics & numerical data
Transplantation, Homologous
Treatment Outcome
Young Adult
Grant Support
ID/Acronym/Agency:
5U01HL069294/HL/NHLBI NIH HHS; U24 CA076518/CA/NCI NIH HHS; U24 CA076518-14/CA/NCI NIH HHS; U24-CA76518/CA/NCI NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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