Document Detail

Outcome of surgery for ileojejunal neuroendocrine tumors.
MedLine Citation:
PMID:  23143168     Owner:  NLM     Status:  Publisher    
PURPOSE: Neuroendocrine tumors (NET) of the ileum/jejunum are rare and may require different treatment options to provide long-term survival. The purpose of the study was to evaluate the outcome of surgery for ileojejunal NET. METHODS: A database of patients that underwent surgery for ileojejunal NETs between 1999 and 2010 was retrospectively analyzed regarding the clinical characteristics, surgical therapy, survival and prognostic factors. RESULTS: Only six of 97 patients with ileojejunal NET who underwent surgery had localized tumors (stage I/II), 29 had lymph node involvement (stage III) and 62 had distant metastases (stage IV) at the initial presentation. All stage I/II tumors were cured, in comparison to 69 % of stage III and 0 % of stage IV tumors (p = 0.01). Palliative surgery in combination with sequential multimodal treatment regimens resulted in a 5-year survival rate of 63 % in patients with stage IV tumors. A multivariate analysis showed that incomplete resection (HR 2.87; CI 1.18-6.98; p = 0.04) and distant metastases (HR 5.39; 95 % CI 1.23-23.57; p = 0.02) were associated with worse disease-specific survival. CONCLUSIONS: Localized and regionally restricted ileojejunal NETs have an excellent prognosis after surgical treatment. Although stage IV tumors cannot be cured, an aggressive surgical approach in combination with medical or interventional treatment can provide long-term survival.
Nils Habbe; Volker Fendrich; Anna Heverhagen; Annette Ramaswamy; Detlef K Bartsch
Related Documents :
23795798 - Unaltered oncological outcomes of radical cystectomy with extended lymphadenectomy over...
2802858 - Efficacy and benefit of mediastinal computed tomography as a selection method for media...
23291658 - Impact of chemotherapy sequencing on local-regional failure risk in breast cancer patie...
15052208 - Results of surgical intervention for p-stage iiia (n2) non-small cell lung cancer: acce...
20960528 - Activity and safety of dose-adjusted infusional cyclophosphamide, doxorubicin, vincrist...
17591568 - Radiotherapy of hodgkin lymphoma: indications, new fields, and techniques.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-11
Journal Detail:
Title:  Surgery today     Volume:  -     ISSN:  1436-2813     ISO Abbreviation:  Surg. Today     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Surgery, University Hospital Marburg, Baldingerstraße, 35043, Marburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Margin-negative limited resection of metastatic pancreatic tumors from rectal cancer preoperatively ...
Next Document:  The efficacy of PET-CT for predicting the malignant potential of gastrointestinal stromal tumors.