Document Detail

Outcome of small-for-gestational age and appropriate-for-gestational age infants born before 27 weeks of gestation.
MedLine Citation:
PMID:  9233975     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the consequences of being small-for-gestational age at extremely low gestational age. METHODOLOGY: Comparison of two historical cohorts of small-for-gestational age (SGA) and appropriate-for-gestational age (AGA) infants born between 24 and 26 6/7 weeks of gestation (gestational age estimated by early ultrasound at 16 to 18 weeks). Data were collected retrospectively on 191 successive admissions to the neonatal intensive care unit between January 1, 1983, and December 31, 1992. These included: demographic and maternal information, delivery mode and condition at birth, mortality, neonatal intensive care unit morbidities (respiratory distress syndrome, intraventricular hemorrhage, patent ductus arteriosis [PDA], chronic lung disease [CLD], retinopathy of prematurity [ROP], necrotizing enterocolitis, infection), nutrition, and length of hospitalization. RESULTS: Forty-one (21%) of the 191 infants were classified as SGA. Those with congenital anomalies (10% in the SGA and 2% in the AGA group) were excluded from further analysis. Despite a similar rate of respiratory distress syndrome (50%), the SGA infants had a greater rate of failure of indomethacin treatment for PDA closure (54% vs 32% for AGA), a higher risk for CLD defined as a need for supplementary oxygen at 36 weeks (65% vs 32% for AGA), a more prolonged need for oxygen supplementation and ventilatory support (94 days vs 68 days for AGA and 58 days vs 40 days for AGA, respectively). SGA infants were also at greater risk for developing severe ROP (stage >/=III) (65% vs 12% for AGA). CONCLUSIONS: For infants born before 27 weeks, being small-for-gestational age confers additional risks for severe morbidity, ie, PDA ligation, CLD, and ROP.
C Bardin; P Zelkowitz; A Papageorgiou
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  100     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1998-09-09     Completed Date:  1998-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E4     Citation Subset:  IM    
Department of Neonatology, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Fetal Growth Retardation / complications
Follow-Up Studies
Infant Mortality
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / epidemiology*,  mortality
Infant, Small for Gestational Age*
Length of Stay / statistics & numerical data
Retrospective Studies

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