| Outcome of severely anaemic fetuses treated by intrauterine transfusions. | |
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MedLine Citation:
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PMID: 19000998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Fetal anaemia is a well-known complication of pregnancy, which might have an ominous effect on the course of pregnancy, labour and the child's development. OBJECTIVE: To assess the effect of the severity of fetal anaemia on the child's outcome. METHODS: A retrospective cohort study. Pregnancies treated by intrauterine transfusions for fetal anaemia at Sheba Medical Center (1996-2004) were divided into two groups: mild to moderate anaemia (fetal haematocrit >0.50 multiples of the median (MoM)) and severe anaemia (hydrops fetalis or fetal haematocrit < or =0.50 MoM). Data were retrieved from relevant obstetric and fetal medicine files. RESULTS: During the study period, 54 fetuses were treated by 154 (median 3; range 1-7) intrauterine transfusions for red cell alloimmunisation. The sensitising antigen was D in 70% of cases; 18/54 patients were sensitised to more than one antigen. Thirty-three of the 54 fetuses (61%) were in the severely anaemic category (haematocrit range 3-20%); six were hydropic. Twenty-one of the 54 fetuses (39%) were in the mild-moderate anaemic category (haematocrit range 20-37%). On prenatal evaluation, there were no sonographic markers of central nervous system abnormalities or intraventricular haemorrhage. There were no differences in the neonatal outcome between the two groups. Developmental outcome was available in 14/18 (78%) mild-moderate cases and 26/29 (89%) severe cases. There were no significant differences in motor development score, percentage of abnormal cognitive development, and percentage of children needing supportive therapy between the mild-moderate and severe cases. CONCLUSION: Neonatal and developmental outcome of fetuses treated for severe anaemia is comparable to cases of mild anaemia. |
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Authors:
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B Weisz; O Rosenbaum; B Chayen; R Peltz; B Feldman; S Lipitz |
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Publication Detail:
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Type: Journal Article Date: 2008-11-10 |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 94 ISSN: 1468-2052 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-22 Completed Date: 2009-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: England |
Other Details:
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Languages: eng Pagination: F201-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. boazmd@zahav.net.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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epidemiology*,
therapy Blood Transfusion, Intrauterine Child Child Development* Child, Preschool Cognition Disorders / epidemiology* Cohort Studies Female Fetal Diseases / epidemiology*, therapy Humans Infant Israel / epidemiology Motor Skills Disorders / epidemiology* Pregnancy Retrospective Studies Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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