Document Detail


Outcome of a second patch test reading of TRUE Tests® on D6/7.
MedLine Citation:
PMID:  23289880     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Background. Two readings of patch test reactions are recommended. Objectives. To evaluate the outcome of a second patch test reading of TRUE Test® allergens on D6/7 in relation to negative or doubtful reactions on D3/4. Methods. This was a retrospective investigation of patch test data from January 1992 to October 2011 from consecutive eczema patients tested with the TRUE Test® panels. Results. In the period of nearly 20 years, a total of 9997 patients were tested. The total number of positive reactions to the 29 allergens was 6509; 4.4% were positive on D6/7 and negative on D3/4; and 9.1% were positive on D6/7 after a doubtful (?+) reaction on D3/4. Neomycin was the most frequent allergen giving delayed positive reactions (57%), followed by budesonide (42%) and hydrocortisone-17-butyrate (31%). Conclusion. A total of 4.4% of positive TRUE Test® reactions would be missed, and 9.1% might be missed, if only one reading was performed on D3/4. The results emphasize that many doubtful reactions at D3/4 may develop into positive reactions at a later reading. This may have important implications for evaluation of the clinical relevance of the test result.
Authors:
Jakob Torp Madsen; Klaus Ejner Andersen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  68     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-14     Revised Date:  2014-07-05    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  England    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / adverse effects
Adult
Age Factors
Allergens / adverse effects*
Dermatitis, Allergic Contact / diagnosis*
Diagnostic Errors / prevention & control
Female
Humans
Male
Neomycin / adverse effects
Patch Tests / methods*
Preservatives, Pharmaceutical / adverse effects
Retrospective Studies
Sex Factors
Time Factors
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Allergens; 0/Preservatives, Pharmaceutical; 1404-04-2/Neomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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