Document Detail

Outcome of second line therapy in rheumatoid arthritis.
MedLine Citation:
PMID:  7864689     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To study the functional outcome in patients with rheumatoid arthritis (RA) who tolerate second line drug therapy for five years. METHODS: We enrolled into prospective controlled trials, 190 patients with rheumatoid arthritis who tolerated 'disease modifying' antirheumatic drug therapy for five years. Demographic data were recorded. Disease activity was measured every six months for two years and annually thereafter, using clinical and laboratory variables. Patient function was measured using the modified Health Assessment Questionnaire. The change in each variable was analysed using paired Wilcoxon tests. RESULTS: Patient function improved significantly compared with baseline. The improvement was maximal after one to two years, and thereafter function started to decline slowly. After five years of treatment the patients' function was still significantly better than before treatment had started. There were highly significant improvements in all variables measured to assess disease activity, which remained well controlled throughout the five year period. CONCLUSION: Good control of disease activity and improved function can be achieved long term in approximately 30% of RA patients treated with injectable gold, sulphasalazine or penicillamine.
D R Porter; I McInnes; J Hunter; H A Capell
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  53     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-03-21     Completed Date:  1995-03-21     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  812-5     Citation Subset:  IM    
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, United Kingdom.
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MeSH Terms
Aged, 80 and over
Antirheumatic Agents / therapeutic use*
Arthritis, Rheumatoid / drug therapy*
Middle Aged
Organogold Compounds
Penicillamine / therapeutic use*
Prospective Studies
Sulfasalazine / therapeutic use*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antirheumatic Agents; 0/Organogold Compounds; 52-67-5/Penicillamine; 599-79-1/Sulfasalazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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