| Outcome of preimplantation genetic diagnosis of translocations. | |
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MedLine Citation:
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PMID: 10856485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review 35 cases of preimplantation genetic diagnosis (PGD) of translocations with several methods, including telomeric probes. DESIGN: Retrospective study. SETTING: Clinical IVF laboratory. PATIENT(s): Thirty-five couples with one partner carrying a chromosomal translocation. INTERVENTION(s): PGD of translocation after polar-body or embryo biopsy. MAIN OUTCOME MEASURE(s): Pregnancy outcome. RESULT(s): Several trends were observed. First, PGD can achieve a statistically significant reduction in spontaneous abortion, from 95% to 13%. Second, the chances of achieving pregnancy are correlated with 50% or more of the embryos being chromosomally normal. Third, patients with robertsonian translocations produced fewer abnormal gametes and more pregnancies than did patients with reciprocal translocations. Fourth, a new fluorescence in situ hybridization protocol for PGD of translocations, which involves applying telomeric probes, has proved adequately reliable with a 6% average error rate. CONCLUSION(s): PGD of translocations achieves a statistically significant reduction in spontaneous abortion, both for polar-body and blastomere biopsy cases. Pregnancy outcome depended on the number of normal embryos available for transfer, with patients having <50% abnormal embryos achieving the most pregnancies. Because robertsonian translocations caused fewer abnormal embryos than reciprocal translocations, they also resulted in higher rates of implantation. |
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Authors:
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S Munné; M Sandalinas; T Escudero; J Fung; L Gianaroli; J Cohen |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 73 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-27 Completed Date: 2000-07-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1209-18 Citation Subset: IM |
Affiliation:
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The Institute for Reproductive Medicine and Science, Saint Barnabas Medical Center, Livingston, New Jersey, USA. santi.munne@embryos.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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prevention & control Adult Chromosome Aberrations / genetics Chromosome Disorders Embryo Implantation Female Humans Male Pregnancy Pregnancy Outcome* Preimplantation Diagnosis* Retrospective Studies Telomere / genetics Translocation, Genetic* |
| Comments/Corrections | |
Comment In:
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Fertil Steril. 2001 Jan;75(1):227-9
[PMID:
11229333
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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