Document Detail

Outcome of pregnancy in women with Marfan's syndrome.
MedLine Citation:
PMID:  9070139     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To improve life expectancy and prevent premature mortality in women with Marfan's syndrome. METHODS: During the development of a regional genetic register for Marfan's Syndrome the outcome of 91 pregnancies in 36 women with this condition was established retrospectively and the cardiovascular and obstetric complications documented. RESULTS: No patient had a significant cardiovascular abnormality limiting function before her pregnancy. Of 36 women, four had an aortic dissection relating to pregnancy and two others required aortic surgery following delivery. Thirty women had uncomplicated gestational histories. The incidence of obstetric complications did not exceed expectation. CONCLUSIONS: Women with Marfan's syndrome are at significant risk of aortic dissection in pregnancy even in the absence of preconceptional cardiovascular abnormality. Aortic root dilatation may be a predictor of risk but dissection may occur without significant dilatation. Guidelines for obstetric care are suggested and preconceptional assessment recommended.
K J Lipscomb; J C Smith; B Clarke; P Donnai; R Harris
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  104     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-10     Completed Date:  1997-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  AIM; IM    
University Department of Cardiology, Manchester Heart Center, Manchester Royal Infirmary, UK.
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MeSH Terms
Aortic Diseases / mortality
Life Expectancy
Marfan Syndrome / mortality*
Pregnancy Complications / mortality*
Pregnancy Complications, Cardiovascular / mortality
Pregnancy Outcome
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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