Document Detail


Outcome of pregnancy in women with cystic fibrosis.
MedLine Citation:
PMID:  7701457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: As women with cystic fibrosis are living longer, pregnancy is becoming increasingly common. The combined experience of pregnancies in women with cystic fibrosis from adult centres in the Midlands and North of England has been examined. METHODS: A retrospective study of the case notes of 22 pregnancies in 20 patients with cystic fibrosis examined changes in lung function, body weight, and microbiological status during the course of pregnancy. Duration of pregnancy, birth weight, and maternal survival were amongst other variables studied. The relation between values before pregnancy and important outcome measures were examined. RESULTS: Eighteen of 22 pregnancies were completed producing healthy, non-cystic fibrosis infants (12 female). Mothers lost 13% of FEV1 and 11% of FVC during pregnancy, most of which was regained. Body weight changes were variable, but most mothers gained weight (mean weight gain 5.7 kg). Microbiological status remained unchanged. Six infants were preterm and two were light for dates. Four mothers died up to 3.2 years following delivery. Of the prepregnancy parameters examined, %FEV1 showed the best correlation with maternal weight gain, gestation, birth weight, and maternal survival. CONCLUSIONS: Pregnancy was well tolerated by most mothers with cystic fibrosis although those with moderate to severe lung disease (%FEV1 < 60%) before pregnancy fared worse, producing preterm infants and suffering increased loss of lung function and mortality compared with mildly affected mothers. Prepregnancy %FEV1 appears to be the most useful predictor of important outcome measures in pregnancies in women with cystic fibrosis.
Authors:
F P Edenborough; D E Stableforth; A K Webb; W E Mackenzie; D L Smith
Related Documents :
2510077 - Uninephrectomy and repetitive pregnancies in mice: a combined stimulus for renal hypert...
7490167 - Mathematical representation of organ growth in the human embryo/fetus.
18282667 - The effect of maternal betel quid exposure during pregnancy on adverse birth outcomes a...
11152907 - Sonographic prediction of twin birth weight discordance.
8039027 - The endocrinology of parturition in the mare.
12478637 - Hypoechogenicity of fetal long bones: a new ultrasound marker for arthrogryposis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thorax     Volume:  50     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-04     Completed Date:  1995-05-04     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  170-4     Citation Subset:  IM    
Affiliation:
Adult Cystic Fibrosis Unit, Birmingham Heartlands Hospital, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Body Weight
Cystic Fibrosis* / physiopathology
Female
Forced Expiratory Volume
Humans
Infant
Infant, Newborn
Infant, Premature
Male
Pregnancy
Pregnancy Outcome*
Retrospective Studies
Vital Capacity
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chest physiotherapy in cystic fibrosis: a comparative study of autogenic drainage and the active cyc...
Next Document:  Vegetarian diet as a risk factor for tuberculosis in immigrant south London Asians.