| Outcome of pregnancy in the rat with mild hyperphenylalaninaemia and hypertyrosinaemia: implications for the management of "human maternal PKU". | |
MedLine Citation:
|
PMID: 3939586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In attempting to determine the effects of mildly elevated maternal phenylalanine (Phe) blood levels on the developing fetal rat brain, a dietary supplement of Phe was given, under taste cover of Aspartame. Phe and tyrosine (Tyr) levels were mildly elevated throughout pregnancy without evidence of malnutrition. Mild hyperphenylalaninaemia with concurrent hypertyrosinaemia induced in rats prior to conception resulted in microcephaly and lasting behavioural problems in the offspring, specifically hyperactivity and learning difficulties. Dams fed Tyr to produce Tyr levels equivalent to the Phe-fed animals showed only the learning difficulties among the offspring. alpha-Methyl Phe, a Phe hydroxylase inhibitor, fed in conjunction with Phe, at the level relevant to these experiments, resulted in raised Tyr levels and does not provide a better method of determining whether mildly elevated maternal Phe levels alone, or Phe and Tyr in combination, cause the abnormality found in the offspring of Phe-supplemented dams. Therapeutic addition of Tyr to diets of mothers with even mild hyperphenylalaninaemia should be approached with caution as mild co-elevation of Phe and Tyr in the fetus may be harmful. In the face of such a possible therapeutic dilemma alternatives, such as dietary additions of other essential amino acids to limit fetal brain damage, need to be explored. |
Authors:
|
S A Lewis; I C Lyon; R B Elliott |
Related Documents
:
|
1663206 - Acute effects of an oral calcium load in pregnancy and lactation: findings on renal cal... 7056226 - Serum calcium and parathyroid hormone during the reproductive cycle in normal and vitam... 3449196 - Apparent dissociation between sympathetic activity and brown adipose tissue thermogenes... 10803696 - Changes in biochemical bone markers during pregnancy and puerperium. 1671366 - Fluorescein angiography in hypertensive pregnancies. 15280106 - Gender differences in amniotic fluid cytokine levels. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of inherited metabolic disease Volume: 8 ISSN: 0141-8955 ISO Abbreviation: J. Inherit. Metab. Dis. Publication Date: 1985 |
Date Detail:
|
Created Date: 1987-03-04 Completed Date: 1987-03-04 Revised Date: 2007-03-21 |
Medline Journal Info:
|
Nlm Unique ID: 7910918 Medline TA: J Inherit Metab Dis Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 113-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain Diseases / etiology* Discrimination (Psychology) Disease Models, Animal* Female Motor Activity Phenylalanine / blood Phenylketonurias* / therapy Pregnancy Pregnancy Complications* / therapy Prenatal Exposure Delayed Effects* Rats Space Perception Tyrosine / blood |
| Chemical | |
Reg. No./Substance:
|
55520-40-6/Tyrosine; 63-91-2/Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transient hyperphenylalaninaemia with a high neopterin to biopterin ratio in urine.
Next Document: Comparative column chromatographic estimations of phenylalanine in plasma, whole blood, native and p...