| Outcome of pregnancy in patients with systemic lupus erythematosus. A prospective study. | |
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MedLine Citation:
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PMID: 1992954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective study was performed to investigate the outcome and complications of pregnancy in patients with systemic lupus erythematosus. Twenty-nine pregnancies occurred in 22 patients. There were 12 abortions, two spontaneous and 10 induced. Fifteen women had 17 live-born neonates. Neonatal complications included nine premature deliveries, two cases of intrauterine growth retardation, and one of Treacher Collins syndrome. Obstetric complications included threatened abortion (two), placenta previa (two), and preeclampsia (three). Cesarean sections were necessary in five patients. There was no maternal or neonatal mortality. Thirteen episodes of systemic lupus erythematosus relapses were detected by incidents of increasing proteinuria (six), arthritis (four), and vasculitic rash (two). There were no statistical differences in changes in hemoglobin level, erythrocyte sedimentation rate, albumin level, antinuclear antibody titer, or C3 or C4 level between the patients who relapsed and those who did not. Pregnancy could induce a flare of systemic lupus erythematosus in previously normal patients or patients with previously inactive disease. The overall neonatal and maternal survival was good, even in patients who presented during pregnancy. Spontaneous fetal loss was low (2/29 [6.9%]); both cases occurred in mothers with inactive lupus. |
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Authors:
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K L Wong; F Y Chan; C P Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of internal medicine Volume: 151 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-14 Completed Date: 1991-03-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 269-73 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Queen Mary Hospital, Hong Kong, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced Adult Female Humans Incidence Infant, Newborn Infant, Newborn, Diseases / epidemiology Lupus Erythematosus, Systemic* / drug therapy Male Pregnancy Pregnancy Complications* / drug therapy Pregnancy Outcome* Prognosis Prospective Studies Recurrence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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